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Metabolomics and lipidomics reveal perturbation of sphingolipid metabolism by a novel anti-trypanosomal 3-(oxazolo[4,5-b]pyridine-2-yl)anilide

ABSTRACT: Trypanosoma brucei is the causative agent of human African trypanosomiasis, which is responsible for thousands of deaths every year. Current therapies are limited and there is an urgent need to develop new drugs. The anti-trypanosomal compound, 3-(oxazolo[4,5-b]pyridine-2-yl)anilide (OXPA), was initially identified in a phenotypic screen and subsequently optimized by structure–activity directed medicinal chemistry. It has been shown to be non-toxic and to be active against a number of trypanosomatid parasites. However, nothing is known about its mechanism of action.

INSTRUMENT(S): Exactive (Thermo Scientific)

SUBMITTER: Darren Creek

PROVIDER: MTBLS360 | MetaboLights | 2017-10-09

REPOSITORIES: MetaboLights

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			Action	DRS
	MTBLS360	Other
	FILES	Other
	a_MTBLS360_metabolite_profiling_mass_spectrometry.txt	Txt
	i_Investigation.txt	Txt
	m_MTBLS360_metabolite_profiling_mass_spectrometry_v2_maf.tsv	Tabular

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