Metabolomics

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Nicotinamide Riboside is Uniquely Bioavailable in People and Mice

ABSTRACT: Nicotinamide riboside (NR) is in wide use as an NAD+ precursor vitamin. Here we conducted experiments to determine the time and dose-dependent effects of NR on blood, liver and heart NAD+ metabolism in people and mice. We report that human blood cell NAD+ can rise as much as 2.7-fold with a single dose of NR, that NR elevates mouse hepatic NAD+ with distinct and superior pharmacokinetics to those of nicotinic acid (NA) and nicotinamide (Nam), and that single doses of 100, 300, and 1000 mg of NR provide a dose-dependent increase in the blood cell NAD+ metabolome in the first clinical trial of NR pharmacokinetics. We also report that nicotinic acid adenine dinucleotide (NAAD), which was not thought to be en route for conversion of NR to NAD+, is formed from NR and that the rise in NAAD is a highly sensitive biomarker of effective NAD+ supplementation.

INSTRUMENT(S): ACQUITY TQD (Waters), Q-TOF Premier (Waters)

SUBMITTER: Samuel Trammell 

PROVIDER: MTBLS368 | MetaboLights | 2016-09-09

REPOSITORIES: MetaboLights

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MTBLS368 Other
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a_MTBLS368_nr_kinetics_metabolite_profiling_mass_spectrometry.txt Txt
a_MTBLS368_nr_mouse_kinetics_metabolite_profiling_mass_spectrometry.txt Txt
i_Investigation.txt Txt
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Nicotinamide riboside is uniquely and orally bioavailable in mice and humans.

Trammell Samuel A J SA   Schmidt Mark S MS   Weidemann Benjamin J BJ   Redpath Philip P   Jaksch Frank F   Dellinger Ryan W RW   Li Zhonggang Z   Abel E Dale ED   Migaud Marie E ME   Brenner Charles C  

Nature communications 20161010

Nicotinamide riboside (NR) is in wide use as an NAD<sup>+</sup> precursor vitamin. Here we determine the time and dose-dependent effects of NR on blood NAD<sup>+</sup> metabolism in humans. We report that human blood NAD<sup>+</sup> can rise as much as 2.7-fold with a single oral dose of NR in a pilot study of one individual, and that oral NR elevates mouse hepatic NAD<sup>+</sup> with distinct and superior pharmacokinetics to those of nicotinic acid and nicotinamide. We further show that single  ...[more]

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