Dataset Information

Impact of myocardial reperfusion on human plasma lipidome

ABSTRACT: The primary aim of the study is to investigate the temporal changes in plasma lipidome before and after reperfusion in patients with ST-segment elevation myocardial infarction (STEMI) and their association with myocardial injury. We found that 56% of the identified lipid species were significantly altered (corrected p< 0.05) in the first 24 h following reperfusion in patients with STEMI. Three lipid species, namely, acylcarnitine 18:2, TG 51:0, and LPC 17:1 were associated with a change in troponin concentration (delta troponin) and in-hospital cardiovascular events. Of these, acylcarnitine 18:2, and LPC 17:1 and their respective whole class levels, were significantly higher (p < 0.05) in the STEMI population than the age/sex-matched control subjects. Overall, our analyses showed a large shift in plasma lipidome in patients that undergo myocardial reperfusion. The differences found for acylcarnitines and LPC species and their association with both cardiac markers and cardiac outcomes need further validation.

INSTRUMENT(S): Liquid Chromatography MS - negative - reverse phase, Liquid Chromatography MS - positive - reverse phase

SUBMITTER: Arun Surendran

PROVIDER: MTBLS3839 | MetaboLights | 2022-02-07

REPOSITORIES: MetaboLights

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Dataset's files

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			Action	DRS
	MTBLS3839	Other
	FILES	Other
	a_MTBLS3839_LC-MS_negative_reverse-phase_metabolite_profiling.txt	Txt
	a_MTBLS3839_LC-MS_positive_reverse-phase_metabolite_profiling-1.txt	Txt
	a_MTBLS3839_LC-MS_positive_reverse-phase_metabolite_profiling.txt	Txt

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Impact of myocardial reperfusion on human plasma lipidome.

Surendran Arun A Atefi Negar N Ismail Umar U Shah Ashish A Ravandi Amir A

iScience 20220129 2

The primary aim of the study is to investigate the temporal changes in plasma lipidome before and after reperfusion in patients with ST-segment elevation myocardial infarction (STEMI) and their association with myocardial injury. We found that 56% of the identified lipid species were significantly altered (corrected p< 0.05) in the first 24 h following reperfusion in patients with STEMI. Three lipid species, namely, acylcarnitine 18:2, TG 51:0, and LPC 17:1 were associated with a change in tropo ...[more]

PMID: 35198888

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