Metabolomics

Dataset Information

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Tissue metabolites in diffuse glioma and their modulations by IDH1 mutation, histology, and treatment


ABSTRACT: The discovery of the oncometabolite 2-hydroxyglutarate in isocitrate dehydrogenase 1-mutated (IDH1-mutated) tumor entities affirmed the role of metabolism in cancer. However, large databases with tissue metabolites that are modulated by IDH1 mutation remain an area of development. Here, we present an unprecedented and valuable resource for tissue metabolites in diffuse glioma and their modulations by IDH1 mutation, histology, and tumor treatments in 101 tissue samples from 73 diffuse glioma patients (24 astrocytoma, 17 oligodendroglioma, 32 glioblastoma), investigated by NMR-based metabolomics and supported by RNA-Seq. We discovered comparison-specific metabolites and pathways modulated by IDH1 (IDH1 mutation status cohort) and tumor entity. The Longitudinal investigation cohort provides metabolic profiles of untreated and corresponding treated glioma samples at first progression. Most interestingly, univariate and multivariate cox regressions and Kaplan-Meier analyses revealed that tissue metabolites correlate with progression-free and overall survival. Thus, this study introduces potentially novel candidate prognostic and surrogate metabolite biomarkers for future prospective clinical studies, aiming at further refining patient stratification in diffuse glioma. Furthermore, our data will facilitate the generation of so-far-unanticipated hypotheses for experimental studies to advance our molecular understanding of glioma biology.

INSTRUMENT(S): Nuclear Magnetic Resonance (NMR) -

SUBMITTER: Christoph Trautwein 

PROVIDER: MTBLS3873 | MetaboLights | 2022-09-07

REPOSITORIES: MetaboLights

Dataset's files

Source:
Action DRS
MTBLS3873 Other
FILES Other
a_MTBLS3873_NMR___metabolite_profiling.txt Txt
files-all.json Other
i_Investigation.txt Txt
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Publications

Tissue metabolites in diffuse glioma and their modulations by IDH1 mutation, histology, and treatment.

Trautwein Christoph C   Zizmare Laimdota L   Mäurer Irina I   Bender Benjamin B   Bayer Björn B   Ernemann Ulrike U   Tatagiba Marcos M   Grau Stefan J SJ   Pichler Bernd J BJ   Skardelly Marco M   Tabatabai Ghazaleh G  

JCI insight 20220208 3


The discovery of the oncometabolite 2-hydroxyglutarate in isocitrate dehydrogenase 1-mutated (IDH1-mutated) tumor entities affirmed the role of metabolism in cancer. However, large databases with tissue metabolites that are modulated by IDH1 mutation remain an area of development. Here, we present an unprecedented and valuable resource for tissue metabolites in diffuse glioma and their modulations by IDH1 mutation, histology, and tumor treatments in 101 tissue samples from 73 diffuse glioma pati  ...[more]

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