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Metabolism Disorder Promotes Isoproterenol-induced Myocardial Injury in Mice with High Temperature and High Humidity and High-Fat Diet

ABSTRACT:

Isoproterenol (ISO) provides a simple and non-invasive method for inducing myocardial injury with lower mortality and higher reproducibility. Phlegm-damp syndrome, as known as “Tanshi” in Chinese, is one of Traditional Chinese Medicine (TCM) syndrome differentiation, which plays an important role in the development of cardiovascular diseases. However, the underlying mechanism remains unknown. In our present study, a myocardial injury mouse model was introduced by ISO administration combined with high temperature and high humidity and high fat diet to simulate phlegm-damp syndrome. Nontargeted metabolomics with LC-MS/MS was adopted to reveal serum metabolism profile for elucidating the possible molecular mechanism.

INSTRUMENT(S): Liquid Chromatography MS - negative - reverse phase, Liquid Chromatography MS - positive - reverse phase

SUBMITTER: Taohua Lan

PROVIDER: MTBLS3886 | MetaboLights | 2022-01-10

REPOSITORIES: MetaboLights

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			Action	DRS
	MTBLS3886	Other
	FILES	Other
	a_MTBLS3886_LC-MS_negative_reverse-phase_metabolite_profiling.txt	Txt
	a_MTBLS3886_LC-MS_positive_reverse-phase_metabolite_profiling.txt	Txt
	files-all.json	Other

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