Dataset Information

Integrated microbiome-metabolome-genome axis data of Laiwu and Lulai pigs

ABSTRACT: Excessive fat deposition can trigger metabolic diseases, and it is crucial to identify factors that can break the link between fat deposition and metabolic diseases. Healthy obese Laiwu pigs (LW) are high in fat content but resistant to metabolic diseases. In this study, we compared the fecal microbiome, fecal and blood metabolome, and genome of LW and Lulai pigs (LU) to identify factors that can block the link between fat deposition and metabolic diseases. Our results show significant differences in Spirochetes and Treponema, which are involved in carbohydrate metabolism, between LW and LU. The fecal and blood metabolome composition was similar, and some anti-metabolic disease components of blood metabolites were different between the two breeds of pigs. The predicted differential RNA is mainly enriched in lipid metabolism and glucose metabolism, which is consistent with the functions of differential microbiota and metabolites. The down-regulated gene RGP1 is strongly negatively correlated with Treponema. Our omics data would provide valuable resources for further scientific research on healthy obesity in both human and porcine.

INSTRUMENT(S): Liquid Chromatography MS - negative - reverse phase, Liquid Chromatography MS - positive - reverse phase

SUBMITTER: Xueshuang Lai

PROVIDER: MTBLS3977 | MetaboLights | 2023-04-20

REPOSITORIES: MetaboLights

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Dataset's files

Source:

			Action	DRS
	MTBLS3977	Other
	FILES	Other
	a_MTBLS3977_LC-MS_20192_neg_metabolite_profiling.txt	Txt
	a_MTBLS3977_LC-MS_20192_pos_metabolite_profiling.txt	Txt
	a_MTBLS3977_LC-MS_20280_neg_metabolite_profiling.txt	Txt

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Publications

Integrated microbiome-metabolome-genome axis data of Laiwu and Lulai pigs.

Lai Xueshuang X Zhang Zhenyang Z Zhang Zhe Z Liu Shengqiang S Bai Chunyan C Chen Zitao Z Qadri Qamar Raza QR Fang Yifei Y Wang Zhen Z Pan Yuchun Y Wang Qishan Q

Scientific data 20230513 1

Excessive fat deposition can trigger metabolic diseases, and it is crucial to identify factors that can break the link between fat deposition and metabolic diseases. Healthy obese Laiwu pigs (LW) are high in fat content but resistant to metabolic diseases. In this study, we compared the fecal microbiome, fecal and blood metabolome, and genome of LW and Lulai pigs (LU) to identify factors that can block the link between fat deposition and metabolic diseases. Our results show significant differenc ...[more]

PMID: 37179393

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