Dataset Information

Fetal Metabolic Stress Disrupts Immune Homeostasis and Induces Proinflammatory Responses in Human Immunodeficiency Virus Type 1- and Combination Antiretroviral Therapy-Exposed Infants

ABSTRACT: Increased morbidity and fetal growth restriction are reported in uninfected children born to human immunodeficiency virus type 1 (HIV-1)–infected women treated with antiretroviral (ARV) therapy. Viruses and/or pharmacological interventions such as ARVs can induce metabolic stress, skewing the cell’s immune response and restricting (cell) growth. Novel metabolomic techniques provided the opportunity to investigate the impact of fetal HIV-1 and combination ARV therapy (cART) exposure on the infants’ immune metabolome. Peroxidized lipids, generated by reactive oxygen species, were increased in cART/HIV-1–exposed infants, indicating altered mitochondrial functioning. The lipid metabolism was further dysregulated with increased triglyceride species and a subsequent decrease in phospholipids in cART/HIV-1–exposed infants compared to control infants. Proinflammatory immune mediators, lysophospholipids as well as cytokines such as CXCL10 and CCL3, were increased whereas anti-inflammatory metabolites from the cytochrome P450 pathway were reduced in cART/HIV-1–exposed infants. Taken together, these data demonstrate that the fetal metabolism is impacted by maternal factors (cART and HIV-1) and skews physiological immune responses toward inflammation in the newborn infant.

INSTRUMENT(S): 6540 Q-TOF LC/MS (Agilent), 6490 Triple Quadrupole LC/MS (Agilent)

SUBMITTER: Michael van Vliet

PROVIDER: MTBLS449 | MetaboLights | 2018-06-06

REPOSITORIES: MetaboLights

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			Action	DRS
	MTBLS449	Other
	FILES	Other
	a_MTBLS449_Non_Polar_mass_spectrometry.txt	Txt
	a_MTBLS449_Oxylipin_mass_spectrometry.txt	Txt
	a_MTBLS449_Polar_mass_spectrometry.txt	Txt

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Fetal Metabolic Stress Disrupts Immune Homeostasis and Induces Proinflammatory Responses in Human Immunodeficiency Virus Type 1- and Combination Antiretroviral Therapy-Exposed Infants.

Schoeman Johannes C JC Moutloatse Gontse P GP Harms Amy C AC Vreeken Rob J RJ Scherpbier Henriette J HJ Van Leeuwen Liesbeth L Kuijpers Taco W TW Reinecke Carools J CJ Berger Ruud R Hankemeier Thomas T Bunders Madeleine J MJ

The Journal of infectious diseases 20170801 4

Increased morbidity and fetal growth restriction are reported in uninfected children born to human immunodeficiency virus type 1 (HIV-1)-infected women treated with antiretroviral (ARV) therapy. Viruses and/or pharmacological interventions such as ARVs can induce metabolic stress, skewing the cell's immune response and restricting (cell) growth. Novel metabolomic techniques provided the opportunity to investigate the impact of fetal HIV-1 and combination ARV therapy (cART) exposure on the infant ...[more]

PMID: 28633455

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