Dataset Information

Evaluation of the toxic effects of municipal wastewater effluent on mice using omic approaches

ABSTRACT: Municipal wastewater effluents (MWWE) contain a lot of trace organic pollutants, which will be a threat to environmental health. However, little information is available for the mixed toxicity of MWWE on mammals. In the present study, male mice were exposed to MWWE for 90 days, and then, histopathology and clinical biochemistry determination and transcriptomic and metabolomic profiling were conducted. The results showed that MWWE exposure resulted in injuries in liver and kidney. Combined transcriptomic and metabolomic data demonstrated that MWWE exposure induced perturbations of metabolism, including lipid, nucleotide, amino acid, and energy metabolism. Furthermore, dysregulation of signal transduction processes were also identified based on differentially expressed genes. These results suggested that chronic exposure to MWWE could induce hepatotoxicity and nephrotoxicity in mice and omic approaches are of practical value to evaluate the complex toxicity of MWWE.

INSTRUMENT(S): Bruker

SUBMITTER: Yan Zhang

PROVIDER: MTBLS48 | MetaboLights | 2018-10-11

REPOSITORIES: MetaboLights

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Dataset's files

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			Action	DRS
	MTBLS48	Other
	FILES	Other
	a_MTBLS48_municipal_omics_analysis_metabolite_profiling_NMR_spectroscopy.txt	Txt
	i_Investigation.txt	Txt
	m_MTBLS48_municipal_omics_analysis_metabolite_profiling_NMR_spectroscopy_v2_maf.tsv	Tabular

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Evaluation of the toxic effects of municipal wastewater effluent on mice using omic approaches.

Zhang Yan Y Huang Kailong K Deng Yongfeng Y Zhao Yanping Y Wu Bing B Xu Ke K Ren Hongqiang H

Environmental science & technology 20130806 16

Municipal wastewater effluents (MWWE) contain a lot of trace organic pollutants, which will be a threat to environmental health. However, little information is available for the mixed toxicity of MWWE on mammals. In the present study, male mice were exposed to MWWE for 90 days, and then, histopathology and clinical biochemistry determination and transcriptomic and metabolomic profiling were conducted. The results showed that MWWE exposure resulted in injuries in liver and kidney. Combined transc ...[more]

PMID: 23883474

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