Metabolomics

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Dynamics of Plasma Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes: Type 1 Diabetes Prediction and Prevention Study (DIPP)


ABSTRACT: Type 1 diabetes (T1D) is one of the most prevalent autoimmune diseases among children in Western countries. Earlier metabolomics studies suggest that T1D is preceded by dysregulation of lipid metabolism. Here we used a lipidomics approach to analyze molecular lipids in a prospective series of 428 plasma samples from 40 children who progressed to T1D (PT1D), 40 children who developed at least a single islet autoantibody but did not progress to T1D during the follow-up (P1Ab) and 40 matched controls (CTR). Sphingomyelins were found to be persistently downregulated in PT1D when compared to the P1Ab and CTR groups. Triacylglycerols and phosphatidylcholines were mainly downregulated in PT1D as compared to P1Ab at the age of 3 months. Our study suggests that children who progressed to islet autoimmunity or overt T1D are characterized by distinct lipidomic signatures, which may be helpful in the identification of at-risk children before the initiation of autoimmunity.

INSTRUMENT(S): API 5000 (AB Sciex)

SUBMITTER: Santosh Lamichhane 

PROVIDER: MTBLS620 | MetaboLights | 2018-07-16

REPOSITORIES: MetaboLights

Dataset's files

Source:
Action DRS
MTBLS620 Other
FILES Other
a_MTBLS620_dipp_tempere_metabolite_profiling_mass_spectrometry.txt Txt
i_Investigation.txt Txt
m_MTBLS620_dipp_tempere_metabolite_profiling_mass_spectrometry_v2_maf.tsv Tabular
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Publications

Dynamics of Plasma Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes - Type 1 Diabetes Prediction and Prevention Study (DIPP).

Lamichhane Santosh S   Ahonen Linda L   Dyrlund Thomas Sparholt TS   Kemppainen Esko E   Siljander Heli H   Hyöty Heikki H   Ilonen Jorma J   Toppari Jorma J   Veijola Riitta R   Hyötyläinen Tuulia T   Knip Mikael M   Oresic Matej M  

Scientific reports 20180713 1


Type 1 diabetes (T1D) is one of the most prevalent autoimmune diseases among children in Western countries. Earlier metabolomics studies suggest that T1D is preceded by dysregulation of lipid metabolism. Here we used a lipidomics approach to analyze molecular lipids in a prospective series of 428 plasma samples from 40 children who progressed to T1D (PT1D), 40 children who developed at least a single islet autoantibody but did not progress to T1D during the follow-up (P1Ab) and 40 matched contro  ...[more]

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