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Oxygen-induced pathological angiogenesis promotes intense lipid synthesis and remodeling in the retina

ABSTRACT:

The retina is a notable tissue with high metabolic needs which relies on specialized vascular networks to protect the neural retina while maintaining constant supplies of oxygen, nutrients and dietary essential fatty acids. Here we analyzed the lipidome of the mouse retina under healthy and pathological angiogenesis using the oxygen-induced retinopathy model. By matching lipid profiles to changes in mRNA transcriptome, we identified a lipid signature showing that pathological angiogenesis leads to intense lipid remodeling favoring pathways for neutral lipid synthesis, cholesterol import/export and lipid droplet formation. Noteworthy, it also shows profound changes in pathways for long-chain fatty acid production, vital for retina homeostasis. The net result is accumulation of large quantities of mead acid, a marker of essential fatty acid deficiency, and a potential marker for retinopathy severity. Thus, our lipid signature might contribute to better understand diseases of the retina that lead to vision impairment or blindness.

INSTRUMENT(S): Liquid Chromatography MS - negative - reverse phase, Liquid Chromatography MS - positive - reverse phase

SUBMITTER: Sayuri Miyamoto

PROVIDER: MTBLS6965 | MetaboLights | 2023-05-09

REPOSITORIES: MetaboLights

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			Action	DRS
	MTBLS6965	Other
	FILES	Other
	a_MTBLS6965_LC-MS_negative_reverse-phase_metabolite_profiling.txt	Txt
	a_MTBLS6965_LC-MS_positive_reverse-phase_metabolite_profiling.txt	Txt
	files-all.json	Other

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