Metabolomics

Dataset Information

0

Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study


ABSTRACT: Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge. Modeling identified 4 PRO clusters based on reported deficits (minimal, physical, mental/cognitive, and multidomain), supporting heterogenous clinical presentations in PASC, with sub-phenotypes associated with female sex and distinctive comorbidities. During the acute phase of disease, a higher respiratory SARS-CoV-2 viral burden and lower Receptor Binding Domain and Spike antibody titers were associated with both the physical predominant and the multidomain deficit clusters. A lower frequency of circulating B lymphocytes by mass cytometry (CyTOF) was observed in the multidomain deficit cluster. Circulating fibroblast growth factor 21 (FGF21) was significantly elevated in the mental/cognitive predominant and the multidomain clusters. Future efforts to link PASC to acute anti-viral host responses may help to better target treatment and prevention of PASC.

INSTRUMENT(S): Q Exactive

SUBMITTER: Joann Diray Arce  Joann Arce 

PROVIDER: MTBLS850 | MetaboLights | 2024-01-12

REPOSITORIES: MetaboLights

altmetric image

Publications

Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study.

Ozonoff Al A   Jayavelu Naresh Doni ND   Liu Shanshan S   Melamed Esther E   Milliren Carly E CE   Qi Jingjing J   Geng Linda N LN   McComsey Grace A GA   Cairns Charles B CB   Baden Lindsey R LR   Schaenman Joanna J   Shaw Albert C AC   Samaha Hady H   Seyfert-Margolis Vicki V   Krammer Florian F   Rosen Lindsey B LB   Steen Hanno H   Syphurs Caitlin C   Dandekar Ravi R   Shannon Casey P CP   Sekaly Rafick P RP   Ehrlich Lauren I R LIR   Corry David B DB   Kheradmand Farrah F   Atkinson Mark A MA   Brakenridge Scott C SC   Higuita Nelson I Agudelo NIA   Metcalf Jordan P JP   Hough Catherine L CL   Messer William B WB   Pulendran Bali B   Nadeau Kari C KC   Davis Mark M MM   Sesma Ana Fernandez AF   Simon Viviana V   van Bakel Harm H   Kim-Schulze Seunghee S   Hafler David A DA   Levy Ofer O   Kraft Monica M   Bime Chris C   Haddad Elias K EK   Calfee Carolyn S CS   Erle David J DJ   Langelier Charles R CR   Eckalbar Walter W   Bosinger Steven E SE   Peters Bjoern B   Kleinstein Steven H SH   Reed Elaine F EF   Augustine Alison D AD   Diray-Arce Joann J   Maecker Holden T HT   Altman Matthew C MC   Montgomery Ruth R RR   Becker Patrice M PM   Rouphael Nadine N  

Nature communications 20240103 1


Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge. Modeling identified 4 PRO clusters based on reported deficits (minimal, physical, mental/cognitive, and multidomain), supporting heterogenous clinical presentations in PASC, with sub-phenotypes associated with female sex and distinctive comorbidities. During t  ...[more]

Similar Datasets

2011-08-31 | E-GEOD-23955 | biostudies-arrayexpress
2021-05-17 | GSE171430 | GEO
2023-09-28 | GSE234486 | GEO
2014-10-31 | E-GEOD-52920 | biostudies-arrayexpress
2022-06-01 | E-MTAB-11237 | biostudies-arrayexpress
2022-06-01 | E-MTAB-11232 | biostudies-arrayexpress
2022-02-08 | E-MTAB-11233 | biostudies-arrayexpress
2022-06-01 | E-MTAB-11234 | biostudies-arrayexpress
2022-06-01 | E-MTAB-11235 | biostudies-arrayexpress
2022-06-01 | E-MTAB-11236 | biostudies-arrayexpress