Dataset Information

Small intestinal microbial dysbiosis underlies symptoms associated with functional gastrointestinal disorders

ABSTRACT: Small intestinal bacterial overgrowth (SIBO) has been implicated in symptoms associated with functional gastrointestinal disorders (FGIDs), though mechanisms remain poorly defined and treatment involves non-specific antibiotics. Here we show that SIBO based on duodenal aspirate culture reflects an overgrowth of anaerobes, does not correspond with patient symptoms, and may be a result of dietary preferences. Small intestinal microbial composition, on the other hand, is significantly altered in symptomatic patients and does not correspond with aspirate culture results. In a pilot interventional study we found that switching from a high fiber diet to a low fiber, high simple sugar diet triggered FGID-related symptoms and decreased small-intestinal microbial diversity and small-intestinal permeability. Our findings demonstrate that characterizing small intestinal microbiomes in patients with gastrointestinal symptoms may allow a more targeted antibacterial or a diet-based approach to treatment.

OTHER RELATED OMICS DATASETS IN: GSE128189

INSTRUMENT(S): Nuclear Magnetic Resonance (NMR)

SUBMITTER: Yi Yang

PROVIDER: MTBLS876 | MetaboLights | 2019-04-30

REPOSITORIES: MetaboLights

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Dataset's files

Source:

			Action	DRS
	MTBLS876	Other
	FILES	Other
	a_MTBLS876_metabolite_profiling_NMR_spectroscopy.txt	Txt
	i_Investigation.txt	Txt
	m_MTBLS876_metabolite_profiling_NMR_spectroscopy_v2_maf.tsv	Tabular

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Small intestinal microbial dysbiosis underlies symptoms associated with functional gastrointestinal disorders.

Saffouri George B GB Shields-Cutler Robin R RR Chen Jun J Yang Yi Y Lekatz Heather R HR Hale Vanessa L VL Cho Janice M JM Battaglioli Eric J EJ Bhattarai Yogesh Y Thompson Kevin J KJ Kalari Krishna K KK Behera Gaurav G Berry Jonathan C JC Peters Stephanie A SA Patel Robin R Schuetz Audrey N AN Faith Jeremiah J JJ Camilleri Michael M Sonnenburg Justin L JL Farrugia Gianrico G Swann Jonathan R JR Grover Madhusudan M Knights Dan D Kashyap Purna C PC

Nature communications 20190501 1

Small intestinal bacterial overgrowth (SIBO) has been implicated in symptoms associated with functional gastrointestinal disorders (FGIDs), though mechanisms remain poorly defined and treatment involves non-specific antibiotics. Here we show that SIBO based on duodenal aspirate culture reflects an overgrowth of anaerobes, does not correspond with patient symptoms, and may be a result of dietary preferences. Small intestinal microbial composition, on the other hand, is significantly altered in sy ...[more]

PMID: 31043597

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