Ontology highlight
ABSTRACT:
INSTRUMENT(S): Gas Chromatography MS - positive, Liquid Chromatography MS - negative - hilic
SUBMITTER: Juan Fernandez-Garcia
PROVIDER: MTBLS8901 | MetaboLights | 2024-03-15
REPOSITORIES: MetaboLights
Action | DRS | |||
---|---|---|---|---|
MTBLS8901 | Other | |||
FILES | Other | |||
a_MTBLS8901_GC-MS_positive__metabolite_profiling.txt | Txt | |||
a_MTBLS8901_LC-MS_negative_hilic_metabolite_profiling.txt | Txt | |||
i_Investigation.txt | Txt |
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Urrutia Andrés A AA Mesa-Ciller Claudia C Guajardo-Grence Andrea A Alkan H Furkan HF Soro-Arnáiz Inés I Vandekeere Anke A Ferreira Campos Ana Margarida AM Igelmann Sebastian S Fernández-Arroyo Lucía L Rinaldi Gianmarco G Lorendeau Doriane D De Bock Katrien K Fendt Sarah-Maria SM Aragonés Julián J
Cell reports 20240411 4
Hypoxia-inducible factor-1α (HIF1α) attenuates mitochondrial activity while promoting glycolysis. However, lower glycolysis is compromised in human clear cell renal cell carcinomas, in which HIF1α acts as a tumor suppressor by inhibiting cell-autonomous proliferation. Here, we find that, unexpectedly, HIF1α suppresses lower glycolysis after the glyceraldehyde 3-phosphate dehydrogenase (GAPDH) step, leading to reduced lactate secretion in different tumor cell types when cells encounter a limited ...[more]