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Dysfunctional lipid metabolism underlies the effect of perinatal DDT exposure on the development of metabolic syndrome

ABSTRACT: Targeted metabolomic analysis of bile acids was performed on 15 mouse liver samples collected from mice euthanized at 9 months following consumption of a high fat diet w/o perinatal DDT exposure. Funded by the National Institute of Health (R00 ES019919, R03 DK082724, U24 DK092993, U24 DK097154, T32 ES007059, and P60 DK020541), the American Diabetes Association, and USDA-ARS intramural Project 5306-51530-019-00D. Samples were analyzed by UPLC-MS/MS using a Waters Acquity UPLC and detected on an API 4000 QTrap (AB Sciex, Framingham, MA, USA) by multiple reaction monitoring (MRM) after negative mode electrospray ionization.

ORGANISM(S): Mouse Mus Musculus

TISSUE(S): Liver

DISEASE(S): Metabolic Syndrome

SUBMITTER: John Newman

PROVIDER: ST000095 | MetabolomicsWorkbench | Thu Jul 10 00:00:00 BST 2014

REPOSITORIES: MetabolomicsWorkbench

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