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Factors for Epigenetic Silencing of Lung Cancer Genes

ABSTRACT: To test the hypothesis that the propensity for silencing of tumor suppressor genes in the respiratory epithelium of chronic smokers by promoter hypermethylation is influenced by sequence variations that modify the activity of genes and microRNAÕs that directly or indirectly influence de novo methylation and chromatin remodeling.

ORGANISM(S): Human Homo Sapiens

TISSUE(S): Blood

DISEASE(S): Cancer

SUBMITTER: Susan Sumner

PROVIDER: ST000104 | MetabolomicsWorkbench | Mon Sep 29 00:00:00 BST 2014

REPOSITORIES: MetabolomicsWorkbench

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