Metabolomics

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Sparing of muscle mass and function by passive loading in an experimental intensive care unit model


ABSTRACT: A unique experimental rat ICU model has been used allowing long-term (weeks) time-resolved analyses of the effects of standardized unilateral passive mechanical loading on skeletal muscle size and function and underlying mechanisms. Results show that passive mechanical loading alleviated the muscle wasting and the loss of force-generation associated with the ICU intervention, resulting in a doubling of the functional capacity of the loaded versus the unloaded muscles after a 2-week ICU intervention.

ORGANISM(S): Rat Rattus Norvegicus

TISSUE(S): Muscle

SUBMITTER: Lars Larsson  

PROVIDER: ST000165 | MetabolomicsWorkbench | Thu May 14 00:00:00 BST 2015

REPOSITORIES: MetabolomicsWorkbench

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