Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Human NK vs T cell metabolism using 13C-Glucose tracer with/out oligomycin (part III)

ABSTRACT: NK versus CD8 T naïve and CD8 T memory SIRM experiment using 13C-Glucose tracer with/out oligomycin

ORGANISM(S): Human Homo Sapiens

TISSUE(S): T-cells

SUBMITTER: Steve Presnell

PROVIDER: ST000951 | MetabolomicsWorkbench | Fri Apr 13 00:00:00 BST 2018

REPOSITORIES: MetabolomicsWorkbench

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	mwtab	Other

Items per page:

1 - 1 of 1

Similar Datasets

Human NK vs T cell metabolism using 13C-Glucose tracer (part I)

Project description:NK versus CD8 T naïve and CD8 T memory SIRM experiment using 13C-Glucose tracer

2018-04-13 | ST000949 | MetabolomicsWorkbench

Human NK vs T cell metabolism using 13C-Glucose tracer with/out galactose (part II)

Project description:NK versus CD8 T naïve and CD8 T memory SIRM experiment using 13C-Glucose tracer with/out galactose

2018-04-13 | ST000950 | MetabolomicsWorkbench

Human NK vs T cell metabolism using 13C-Glucose tracer with/out oligomycin and galactose (part IV)

Project description:Human NK vs T cell metabolism using 13C-Glucose tracer with/out oligomycin and galactose

2018-04-13 | ST000952 | MetabolomicsWorkbench

FASN effect on HCT116 metabolism probed by 13C6-glucose tracer (part II)

Project description:13C6-glucose tracer used to track the effects of FASN on KM20 cells metabolism

2018-08-31 | ST001046 | MetabolomicsWorkbench

FASN effect on HCT116 metabolism probed by 13C6-glucose tracer (part I)

Project description:13C6-glucose tracer used to track the effects of FASN on HCT116 CRC cells metabolism

2018-08-31 | ST001045 | MetabolomicsWorkbench

Memory like NK cells display stem cell like properties after Zika virus Infection

Project description:Here we show that Zika virus infection induces memory like NK cells that express CD27. This subset shared transcriptional changes with memory CD8 T cells, stem cells and stem like T cells. These NK cells with memory and stemness features which we term NK memory stem cells (SCMNK) demonstrated greater antiviral potential. Transcriptional data of SCMNK and non-memory NK cells is presented.

2020-12-11 | GSE148205 | GEO

Effect of anti-IL-15 administration on T cell and NK cell homeostasis in rhesus macaques (TCM)

Project description:Analysis of the effect of anti-IL-15 monoclonal antibody treatment on T cell and NK cell homeostasis in rhesus macaques. The hypothesis tested in the present study was that repeated administrations of a rhesusized anti-IL-15 monoclonal antibody would block IL-15 activity in vivo and result in changes to T and/or NK cell population dynamics that would reflect physiologic IL-15 function. The results provide important information on the specific role IL-15 plays in effector memory T cell and NK cell homeostasis, noting that effector memory T cells but not NK cells can be maintained in the absence of IL-15 signaling by the activity of other cytokines. Sort-purified CD8+ and CD4+ TCM from PBMC, before and after treatment with IgG1 Ab and anti-IL15 Ab

2016-09-07 | E-GEOD-76785 | biostudies-arrayexpress

Effect of anti-IL-15 administration on T cell and NK cell homeostasis in rhesus macaques (TEM)

Project description:Analysis of the effect of anti-IL-15 monoclonal antibody treatment on T cell and NK cell homeostasis in rhesus macaques. The hypothesis tested in the present study was that repeated administrations of a rhesusized anti-IL-15 monoclonal antibody would block IL-15 activity in vivo and result in changes to T and/or NK cell population dynamics that would reflect physiologic IL-15 function. The results provide important information on the specific role IL-15 plays in effector memory T cell and NK cell homeostasis, noting that effector memory T cells but not NK cells can be maintained in the absence of IL-15 signaling by the activity of other cytokines. Sort-purified CD8+ TEM from PBMC, before and after treatment with IgG1 Ab and anti-IL15 Ab

2016-09-07 | E-GEOD-76796 | biostudies-arrayexpress

Patient-derived parathyroid organoids as tracer and drug-screening application model

Project description:Parathyroid diseases are characterized by dysregulation of calcium homeostasis and alterations in parathyroid hormone (PTH) excretion. The understanding of parathyroid hyperplastic growth and the development of tracers for imaging and treatment could benefit from in vitro models. Therefore, we aim to establish stem cell-derived three-dimensional organoids representing human parathyroid tissue in vitro. Patient-derived hyperplastic parathyroid tissue was dispersed and parathyroid organoids (PTO) were cultured, characterized by immunofluorescence, and RNA-sequencing was performed. Functional PTO testing was performed by calcium-response measurements, drug screening, PET (11C-methionine) and SPECT-tracer (99mTc-sestamibi) validation. PTO in vitro self-renewal potential was assessed to show the presence of putative stem cells. RNA-sequencing confirms that PTO phenocopy hyperplastic parathyroid tissue. Exposure to increasing calcium concentrations and to PTH-lowering drugs, resulted in a significantly reduced PTH excretion. Next to this, the PTO showed specific binding of 11C-methionine to the targeted receptor. Additionally, when organoids were incubated with 99mTc-sestamibi, we observed a higher uptake in PTOs from patients with a positive scan compared to patients with a negative scan. In conclusion, we present a patient-derived PTO culture, that recapitulates the originating tissue on gene and protein expression and functionality. We demonstrate the potential of PTOs for physiology studies and therapeutic target and tracer discovery.

2022-02-28 | GSE197445 | GEO

Kim2014 - Tumor model under immune suppression

Project description:its a mathematical model explaining the impact of chemotherapy and immunotherpay together on Tumor cells involving cytokines like Il2, IL10 and TGFbeta, immune cells like CD4+ T cells, CD8+ T cells, Memory T cells, NK cells, dendrtic cells. This model is based on the previous model published by Robertson-Tessi M 2012 (PMID:22051568).

2019-09-25 | MODEL1909240002 | BioModels

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data