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Characterization of metabolomics profile changes during development of post-traumatic epilepsy in Rat Cerebrospinal Fluid (part-II)

ABSTRACT: Characterize the metabolomics profile changes during progression of the transition from traumatic brain injury (TBI) to post-traumatic epilepsy (PTE). To do so, three experiments will be performed. PTE animal model will be developed using ferrous chloride injections. Metabolomics profile changes will be obtained before TBI, after TBI, and after PTE development These temporal changes in metabolomics profile during the course of PTE development will be collected. We will also collect cerebrospinal fluid (CSF) at each time point. In addition, we will collect the brain tissue from the center of injury, around the injury, and from the non-injured area for mass spectrometry. In this study, Rat CSF is analyzed at end of study.

ORGANISM(S): Rat Rattus Norvegicus

TISSUE(S): Cerebrospinal Fluid

DISEASE(S): Epilepsy

SUBMITTER: Chang Su-youne

PROVIDER: ST001021 | MetabolomicsWorkbench | Tue Jul 17 00:00:00 BST 2018

REPOSITORIES: MetabolomicsWorkbench

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