Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Multi-platform metabolomics data from Ndufs4-/- skeletal muscles (part-II)

ABSTRACT: Targeted analysis of amino acids and acylcarnitines in mouse Ndufs4-/- and WT soleus muscles

ORGANISM(S): Mouse Mus Musculus

TISSUE(S): Muscle

DISEASE(S): Leigh Syndrome

SUBMITTER: Roan Louw

PROVIDER: ST001077 | MetabolomicsWorkbench | Tue Oct 16 00:00:00 BST 2018

REPOSITORIES: MetabolomicsWorkbench

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	mwtab	Other

Items per page:

1 - 1 of 1

Similar Datasets

Multi-platform metabolomics data from Ndufs4-/- skeletal muscles (part-IV)

Project description:Untargeted GC-TOF-MS analysis of Ndufs4-/- and WT mouse soleus muscles.

2018-10-18 | ST001085 | MetabolomicsWorkbench

Multi-platform metabolomics data from Ndufs4-/- skeletal muscles (part - I)

Project description:Targeted LC-MS/MS analysis of amino acids and acylcarnitines in Ndufs4-/- and WT mouse white quadriceps muscles.

2018-10-17 | ST001076 | MetabolomicsWorkbench

Multi-platform metabolomics data from Ndufs4-/- skeletal muscles (part-V)

Project description:NMR analysis of Ndufs4-/- and WT mouse white quadriceps muscles

2018-10-18 | ST001078 | MetabolomicsWorkbench

Multi-platform metabolomics data from Ndufs4-/- skeletal muscles (part -III)

Project description:Untargeted GC-TOF-MS analysis of Ndufs4-/- and WT mouse white quadriceps muscles.

2018-10-18 | ST001084 | MetabolomicsWorkbench

Effect of muscular dystrophy caused by PTRF deletion on the transcriptome of skeletal muscles

Project description:Muscular dystrophy is a group of diseases that cause progressive weakness and degeneration of the skeletal muscles that control movement. Lacking the caveolae component polymerase I transcription release factor (PTRF) causes a secondary deficiency of caveolins resulting in muscular dystrophy. To investigate the effect of PTRF deletion on skeletal muscle, we created gene-edited mice with PTRF knockout (KO). We then performed RNA-seq of soleus and quadriceps muscles from soleus and quadriceps muscles of 3 months old WT (n=3) and PTRF KO mice (n=3) and analyzed the data for gene expression profiling. 12933 genes were detected across all 12 libraries. The hierarchy clustering of co-expressed genes revealed a clear split between PTRF KO and WT mice for both skeletal muscles. Differential expression analysis identified 1293 and 705 differentially expressed genes (DEGs) in the soleus and quadriceps, respectively. 971 and 534 DEGs were up-regulated, and 322 and 171 DEGs were down-regulated in the soleus and quadriceps of PTRF KO mice, respectively.

2023-05-31 | GSE217389 | GEO

Expression data from skeletal muscles of Ts1Cje and disomic C57BL/6 mice

Project description:To determine the gene expression profile of extensor digitorum longus (EDL) and soleus (SO) muscles of wild-type and Ts1Cje mouse model of Down Syndrome (DS). Two types of skeletal muscles (EDL and SO) were harvested from both Ts1Cje and its disomic littermate.

2018-09-06 | GSE96572 | GEO

Transcription profiling of mouse Ostesy mutant soleus muscles vs wild type soleus muscles.

Project description:A comparison of Ostesy mutant soleus muscles to wildtype soleus muscles. Hybridisation of 3 Mouse SGC 7.5k oligo arrays, using 3 pools of 10 mice(5 male and 5 female) for mutant and WT.

2007-12-10 | E-MEXP-482 | biostudies-arrayexpress

Transcription profiling of Ky mouse mutant soleus muscles vs wild type soleus muscles

Project description:A comparison of Ky mouse mutant soleus muscles versus wildtype soleus muscles. Hybridisation of 3 Mouse SGC 7.5k oligo slides, using 3 independent pools of 10 mice (5 male, 5 female)for both WT and mutant animals.

2005-11-10 | E-MEXP-481 | biostudies-arrayexpress

Transcription profiling of mouse Ostes mutant soleus muscle vs wild type soleus muscles

Project description:A comparison of Ostes homozygous mutant soleus muscles to wildtype soleus muscles. Hybridisation of 3 Mouse CNG 25k oligo arrays, using 3 pools of 10 mice(5 male and 5 female) for mutant and WT.<br><br>

2009-09-17 | E-MEXP-1873 | biostudies-arrayexpress

MiRNA expression profiling of skeletal muscles in aged rodents

Project description:Skeletal muscle atrophy is one of the critical issues which elderly people face. The precise mechanism underlying muscle atrophy during aging is not fully understood. In order to identify miRNA whose expression is changed in age-associated muscle atrophy, we performed miRNA expression profiling of skeletal muscles in young and aged rats. Microarray analysis revealed differential miRNA expression in EDL and soleus muscles of aged rats compared with those of young rats. We next investigated whether the age-associated changes of miRNA expression observed in rats were recapitulated in mice and found that the expression level of miR-206 in EDL muscle and that of miR-196a in EDL and soleus muscles were respectively higher and lower in aged rodents than in young rodents. In mouse C2C12 myoblasts and myotubes, introduction of miR-196a decreased the protein level of Forkhead-box transcription factor Foxo1, a known target of miR-196a, indicating that miR-196a may regulate Foxo1 expression also in skeletal muscles. Furthermore, miR-196a overexpression exacerbated cell death caused by an exposure to hydrogen peroxide. Lastly, we demonstrated that expression of Foxo1 was elevated in EDL and soleus muscles of aged mice compared with those of young mice. These results suggest that miRNAs are involved in skeletal muscle atrophy during aging and that decreased miR-196a expression may protect skeletal muscle cells from oxidative stress in part through induction of Foxo1.

2016-08-31 | GSE70990 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data