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Early Mechanistic Events Induced by Secondhand Smoke Prevalent Low Molecular Weight Polycyclic Aromatic Hydrocarbons in Mouse Lung Epithelial Cells

ABSTRACT: We evaluated lung epithelial cells exposed to low molecular weight polycyclic aromatic hydrocarbons and what lipid metabolites were produced following early exposure, prior to metabolism. For the targeted study (AKB study 2, we used 40uM dose of the 2PAHs (1methylanthracene and fluoranthene; 1:1 ratio)and assessed 2,4,8,and 12 hrs of treatment with the PAHs. We also examined a 24 h time point in another study at a lower dose (15 uM LMW PAH mixture; 1:1 ratio of 1-methanthrancene and fluoranthene).

ORGANISM(S): Mouse Mus Musculus

TISSUE(S): Epithelial Cells

DISEASE(S): Lung Disease

SUBMITTER: Alison Bauer

PROVIDER: ST001124 | MetabolomicsWorkbench | Tue Nov 06 00:00:00 GMT 2018

REPOSITORIES: MetabolomicsWorkbench

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