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Ontogeny related changes in the pediatric liver metabolome

ABSTRACT: A major challenge in implementing personalized medicine in pediatrics is identifying appropriate drug dosages for children. The majority of drug dosing studies have been based on adult populations, often with modification of the dosing for children based on size and weight. However, the growth and development experienced by children between birth and adulthood represents a dynamically changing biological system, with implications for effective drug dosing, efficacy as well as potential drug toxicity. The purpose of this study was to apply a metabolomics approach to gain preliminary insights into the ontogeny of liver function from newborn to adolescent.

ORGANISM(S): Human Homo Sapiens

TISSUE(S): Liver

SUBMITTER: Brooke Fridley

PROVIDER: ST001402 | MetabolomicsWorkbench | Wed May 27 00:00:00 BST 2020

REPOSITORIES: MetabolomicsWorkbench

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Project description:A major challenge in implementing personalized medicine in pediatrics is identifying appropriate drug dosages for children. The majority of drug dosing studies have been based on adult populations, often with modification of the dosing for children based on size and weight. However, the growth and development experienced by children between birth and adulthood represents a dynamically changing biological system, with implications for effective drug dosing, efficacy as well as potential drug toxicity. The purpose of this study was to apply a metabolomics approach to gain preliminary insights into the ontogeny of liver function from newborn to adolescent.

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Project description:IGNITE: Genomic Medicine Implementation - The Personalized Medicine Program

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An Organoid Biobank for Childhood Kidney Cancers that Captures Disease and Tissue Heterogeneity

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A "living biobank" of Crohn's Disease

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Comparison of primary vs immortalized HUVEC

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2018-02-28 | GSE110085 | GEO

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