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The effect of fasting and sirtuin overexpression on serum metabolome.

ABSTRACT: The levels of the sirtuins SIRT1 and SIRT6 are regulated by nutrient availability in several mammalian tissues. In addition, overexpressing SIRT1 in mice improves healthspan, while SIRT6 overexpression increases both healthspan and lifespan. However, little is known about the impact of these sirtuins at the in vivo metabolomics level. Thus, we performed metabolomics on serum taken from 15 months old male mice overexpressing SIRT1, SIRT6 and SIRT1+SIRT6 as well as WT controls. Sera were obtained from mice at three nutritional time points - at fed state, after 4h morning fast and after 16h fast.

ORGANISM(S): Mouse Mus Musculus

TISSUE(S): Blood

SUBMITTER: Haim Cohen

PROVIDER: ST001523 | MetabolomicsWorkbench | Thu Sep 10 00:00:00 BST 2020

REPOSITORIES: MetabolomicsWorkbench

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