Metabolomics

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Dietary composition analysis of chow diet and purified diet using untargeted metabonomics


ABSTRACT: Dietary patterns and psychosocial factors, ubiquitous part of modern lifestyle, critically shape the gut microbiota and human health. However, it remains obscure how dietary and psychosocial inputs coordinately modulate the gut microbiota and host impact. Here, we show that dietary raffinose metabolism to fructose couples stress-induced gut microbial remodeling to intestinal stem cells (ISC) renewal and epithelial homeostasis. Chow diet (CD) and purified diet (PD) confer distinct vulnerability to gut epithelial injury, microbial alternation and ISC dysfunction in chronically restrained mice. CD preferably enriches Lactobacillus reuteri, and its colonization is sufficient to rescue stress-triggered epithelial injury.

ORGANISM(S): Food Item -

TISSUE(S): Diet

SUBMITTER: Hou Yuanlong  

PROVIDER: ST001620 | MetabolomicsWorkbench | Wed Dec 09 00:00:00 GMT 2020

REPOSITORIES: MetabolomicsWorkbench

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