Metabolomics

Dataset Information

0

Atypical Molecular Basis for Drug Resistance to Mitochondrial AQ: A Function Inhibitors in Plasmodium falciparum


ABSTRACT: In this study, we present a clear genotype for the P. falciparum SB1-A6 acridone-resistant clonal parasite strain and, through a combination of targeted and whole-cell methods, establish that the mechanism of resistance to both cytochrome bc1 and DHODH inhibitors results from the contribution of multiple genetic polymorphisms. We find that P. falciparum SB1-A6 accumulates both a copy number variation and a specific mutation in PfDHODH, and both of these genetic polymorphisms contribute to the panresistant phenotype. This study uncovers a mechanism of cross-resistance between PfDHODH and mtETC inhibitors and serves as a cautionary note to future antimalarial combination therapy formulations containing such drugs.

ORGANISM(S): Plasmodium Falciparum

TISSUE(S): Plasmodium Cells

DISEASE(S): Malaria

SUBMITTER: Heather Painter  

PROVIDER: ST001652 | MetabolomicsWorkbench | Sun Jan 17 00:00:00 GMT 2021

REPOSITORIES: MetabolomicsWorkbench

Dataset's files

Source:
Action DRS
mwtab Other
Items per page:
1 - 1 of 1

Similar Datasets

2021-02-10 | MSV000086838 | GNPS
2013-06-03 | E-GEOD-47579 | biostudies-arrayexpress
2013-06-03 | GSE47579 | GEO
2012-07-19 | E-GEOD-39485 | biostudies-arrayexpress
2014-03-06 | E-GEOD-55624 | biostudies-arrayexpress
2012-07-20 | GSE39485 | GEO
2010-07-01 | E-GEOD-5267 | biostudies-arrayexpress
2019-12-20 | PXD013539 | Pride
2007-07-31 | GSE4582 | GEO
2022-01-21 | GSE176469 | GEO