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Metabolomics of mouse blood sera comparing GF and CONV-R mice

ABSTRACT: Using high coverage metabolomics, we profiled feces, blood sera and cerebral cortical brain tissues of germ-free C57BL/6 mice and their age-matched conventionally raised counterparts. Results revealed for all three sample matrices metabolomic signatures owing to microbiota, yielding hundreds of identified metabolites including 533 altered for feces, 231 for sera and 58 for brain tissues with numerous significantly enriched pathways involving aromatic amino acids and neurotransmitters.

ORGANISM(S): Mouse Mus Musculus

TISSUE(S): Blood

SUBMITTER: Yunjia Lai

PROVIDER: ST001757 | MetabolomicsWorkbench | Wed Apr 28 00:00:00 BST 2021

REPOSITORIES: MetabolomicsWorkbench

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Metabolomics of mouse feces comparing GF and CONV-R mice

Project description:Using high coverage metabolomics, we profiled feces, blood sera and cerebral cortical brain tissues of germ-free C57BL/6 mice and their age-matched conventionally raised counterparts. Results revealed for all three sample matrices metabolomic signatures owing to microbiota, yielding hundreds of identified metabolites including 533 altered for feces, 231 for sera and 58 for brain tissues with numerous significantly enriched pathways involving aromatic amino acids and neurotransmitters.

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