Searching for prognostic biomarkers of Parkinson´s Disease development in the Spanish EPIC cohort through a multiplatform metabolomics approach
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ABSTRACT: The lack of knowledge about the onset and progression of Parkinson’s disease (PD) hampers its early diagnosis and treatment. We used a multiplatform untargeted metabolomics-based approach to uncover the biochemical remodeling induced by PD in a really early and pre-symptomatic stage and unveiling early potential diagnostic biomarkers. Baseline pre-clinical plasma samples (Pre-PD n=39; control group n=39) were obtained from the European Prospective Study on Nutrition and Cancer (EPIC) cohort, which healthy volunteers were followed for around 15 years to ascertain incident PD. Our finding revealed alterations in fatty acids metabolism, mitochondrial dysfunction, oxidative stress, and gut-brain axis dysregulation. This study is of inestimable value since this is the first study conducted with samples collected many years before the disease development.
ORGANISM(S): Human Homo Sapiens
TISSUE(S): Blood
DISEASE(S): Parkinsons Disease
SUBMITTER: Carolina Gonzalez-Riano
PROVIDER: ST001814 | MetabolomicsWorkbench | Tue Jun 01 00:00:00 BST 2021
REPOSITORIES: MetabolomicsWorkbench
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