Metabolomics

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Metabolite profiling of Malaysian Gracilaria edulis reveals Eplerenone as novel antibacterial compound for drug repurposing against MDR Bacteria


ABSTRACT: The current study re-defines a method to reveal bioactive compounds from the crude extracts of Malaysian red seaweed Gracilaria edulis, having promising antibacterial activities against selected bacterial species. Three species of Gram-positive and - negative characters were remarkably inhibited by the sequential and direct extracts of ethyl acetate and acetone. These were further separated through chromatographic methods to reveal a plethora of chemical constituents to be considered for a downstream virtual screening against selected crucial proteins of the six bacteria.

ORGANISM(S): Gracilaria Edulis Malaysian Red Seaweed

TISSUE(S): Seaweed

SUBMITTER: Chandrajit Lahiri  

PROVIDER: ST001839 | MetabolomicsWorkbench | Tue Apr 13 00:00:00 BST 2021

REPOSITORIES: MetabolomicsWorkbench

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