Metabolomics

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The apicomplexan parasite Toxoplasma gondii forms bradyzoite-containing tissue cysts that cause chronic and drug-tolerant infections.


ABSTRACT: The apicomplexan parasite Toxoplasma gondii forms bradyzoite-containing tissue cysts that cause chronic and drug-tolerant infections. Here, we developed a human myotube-based in vitro culture model of functionally mature tissue cysts. Metabolomic characterization of purified cysts reveals global changes that comprise increased levels of amino acids and decreased abundance of nucleobase- and tricarboxylic acid cycle-associated metabolites. In contrast to fast replicating tachyzoite forms of T. gondii these tissue cysts tolerate exposure to the aconitase inhibitor sodium fluoroacetate.

ORGANISM(S): Toxoplasma Gondii

TISSUE(S): Cultured Cells

DISEASE(S): Parasitic Infection

SUBMITTER: Martin Blume  

PROVIDER: ST002051 | MetabolomicsWorkbench | Tue Jan 04 00:00:00 GMT 2022

REPOSITORIES: MetabolomicsWorkbench

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