The apicomplexan parasite Toxoplasma gondii forms bradyzoite-containing tissue cysts that cause chronic and drug-tolerant infections.
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ABSTRACT: The apicomplexan parasite Toxoplasma gondii forms bradyzoite-containing tissue cysts that cause chronic and drug-tolerant infections. Here, we developed a human myotube-based in vitro culture model of functionally mature tissue cysts. Metabolomic characterization of purified cysts reveals global changes that comprise increased levels of amino acids and decreased abundance of nucleobase- and tricarboxylic acid cycle-associated metabolites. In contrast to fast replicating tachyzoite forms of T. gondii these tissue cysts tolerate exposure to the aconitase inhibitor sodium fluoroacetate.
ORGANISM(S): Toxoplasma Gondii
TISSUE(S): Cultured Cells
DISEASE(S): Parasitic Infection
SUBMITTER: Martin Blume
PROVIDER: ST002051 | MetabolomicsWorkbench | Tue Jan 04 00:00:00 GMT 2022
REPOSITORIES: MetabolomicsWorkbench
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