Chemoresistant Cancer Cell Lines are Characterized by Migratory, Amino Acid Metabolism, Protein Catabolism and IFN1 Signalling Perturbations
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ABSTRACT: Our analysis was able to separate chemoresistant cells from their parental cells based on their metabolomic and proteomic features and identified altered biological processes and pathways which are of further interest. Preliminary investigation of patient-derived cells highlighted the need to perform broad biological and molecular analyses, compre-hensive in vitro and in vivo studies, using a larger patient cohort to achieve a deeper and clinically relevant characterization of the molecular drivers of chemoresistance.
ORGANISM(S): Human Homo Sapiens
TISSUE(S): Cultured Cells
DISEASE(S): Cancer
SUBMITTER: Mitchell Acland
PROVIDER: ST002104 | MetabolomicsWorkbench | Sun Feb 06 00:00:00 GMT 2022
REPOSITORIES: MetabolomicsWorkbench
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