Global metabolomics analysis of neutrophils isolated from tumor
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ABSTRACT: Pathologically activated neutrophils (PMN), termed myeloid-derived suppressor cells (PMN-MDSCs), are major negative regulators of anti-tumor immunity. The mechanisms responsible for the pathological activation of neutrophils upon infiltration into tumors are not well defined, thus limiting the selective targeting of these cells. Tumor cells and immune cells engage in bi-directional manipulation of their respective metabolism, thereby altering cell function to facilitate tumor progression. Targeting the metabolism of responding immune cells can improve cancer treatment when combined with existing therapeutic strategies. Here, we investigated the role of metabolism in the immunoinhibitory actions of tumor PMN-MDSCs.
ORGANISM(S): Mouse Mus Musculus
TISSUE(S): Tumor Cells
DISEASE(S): Cancer
SUBMITTER: Yulia Nefedova
PROVIDER: ST002160 | MetabolomicsWorkbench | Wed May 04 00:00:00 BST 2022
REPOSITORIES: MetabolomicsWorkbench
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