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Individualized exercise intervention for people with multiple myeloma improves quality of life in a randomized controlled trial

ABSTRACT: Although new treatments have improved survival for multiple myeloma (MM), quality of life remains poor for people with this incurable cancer. We conducted a multi-site randomized, waitlist-controlled trial of an individualized exercise program for people at all stages of MM (n=60). Compared to the waitlist control group, participants of the 12-week intervention had significant improvement in health-related quality of life, mediated through improved MM symptoms, cardiorespiratory fitness and bone pain, with were mostly maintained at follow-up (up to 12 months). Exploratory plasma metabolomics and lipidomics was conducted to delineate molecular mechanisms and biomarkers

ORGANISM(S): Human Homo Sapiens

TISSUE(S): Blood

DISEASE(S): Multiple Myeloma

SUBMITTER: Thomas Stoll

PROVIDER: ST002183 | MetabolomicsWorkbench | Wed Jun 01 00:00:00 BST 2022

REPOSITORIES: MetabolomicsWorkbench

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Individualized exercise intervention for people with multiple myeloma improves quality of life in a randomized controlled trial

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