An early-life microbiota metabolite protects against obesity via intestinal PPAR-gamma
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ABSTRACT: The mechanisms by which the early-life microbiota protects against environmental factors that promote childhood obesity remain largely unknown. Using a mouse model in which young mice are simultaneously exposed to antibiotics and a high-fat diet, we show that Lactobacillus species, predominant members of the small intestine microbiota, regulate intestinal epithelial cells (IECs) to limit diet-induced obesity during early-life. A Lactobacillus-derived metabolite, phenyllactic acid (PLA), protected against metabolic dysfunction caused by early-life exposure to antibiotics and a high-fat diet by increasing the abundance of peroxisome proliferator activated receptor gamma (PPAR-gamma) in the small intestine IECs. Therefore, PLA is a microbiota-derived metabolite that activates protective pathways in the small intestine epithelium to regulate fat absorption and prevent obesity during early life.
ORGANISM(S): Mouse Mus Musculus
TISSUE(S): Feces
SUBMITTER: Simona Gabriella Codreanu
PROVIDER: ST002186 | MetabolomicsWorkbench | Fri Jun 03 00:00:00 BST 2022
REPOSITORIES: MetabolomicsWorkbench
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