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The effects of PKM2 modulation and hypoxia on the metabolic landscape of Alzheimer patient-derived induced neurons

ABSTRACT: We have obtained fibroblast cultures from old adult human non-demented control donors and Alzheimer patients (AD). The fibroblasts were reprogrammed into directly induced neurons (iNs) to serve as an adult-like and age-equivalent model for aging and neurodegeneration. Their response to PKM2 modulation (shikonin 10 µM or PKM2 overexpression) and hypoxia (CoDo treatment) were assessed.

ORGANISM(S): Human Homo Sapiens

TISSUE(S): Fibroblast Cells

DISEASE(S): Alzheimers Disease

SUBMITTER: Julie Haines

PROVIDER: ST002214 | MetabolomicsWorkbench | Fri Jun 24 00:00:00 BST 2022

REPOSITORIES: MetabolomicsWorkbench

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