Investigating metabolic pathways of pediatric obesity (urine)

ABSTRACT: The pediatric obesity influences all the organs and is closely linked to an increased risk of diverse diseases such as diabetes, cardiovascular, stroke, social problems and depression. Therefore, there is needed to diverse study for effective methods for the prevention and treatment of pediatric obesity. Diverse evidences suggest that gut microbiome and its metabolites affect metabolic disease such as obesity, diabetes, and heart disease. Previous studies in human and fecal transplantation experiments in animal models identified connections between the metabolic diseases and gut microbiota [4]. Moreover, metabolites can be fulfilled as diagnostic, prognostic, and therapeutic targets for diseases. Thus, approaches using metagenomics and metabolomics have the potential to provide new insights into metabolomic pathways of the diseases and help personalized and efficient treatments. In this study, we aimed to investigate metabolomic pathways of pediatric obesity analyzing both metabolome and microbiome profiles. In addition, we proceeded obese intervention with obese children to examine underlying metabolomic pathways related to effect of the intervention.

ORGANISM(S): Human Homo Sapiens

TISSUE(S): Urine

DISEASE(S): Obesity

SUBMITTER: Yujin Lee  

PROVIDER: ST002261 | MetabolomicsWorkbench | Mon Jul 04 00:00:00 BST 2022

REPOSITORIES: MetabolomicsWorkbench