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Characterizing the intrauterine environment via untargeted metabolomics profiling of maternal blood collected during pregnancy (Project Viva)

ABSTRACT: Project Viva: Pregnant women were enrolled in Project Viva between 1999 and 2002 at their first prenatal visit at one of 8 obstetric clinics of Atrius Harvard Vanguard Medical Associates, a multispecialty group practice in eastern Massachusetts. Eligible mothers were fluent in English, had singleton gestations, were <22 weeks gestation, and had no plans to move away from the study area. Research staff performed in-person study visits with participating mothers in the first (median gestational age 9.9 weeks) and second (median gestational age 28.1 weeks) trimesters of pregnancy, and with mothers and children during the first few days after delivery, during infancy (median age 6.3 months), in early childhood (median age 3.3 years), mid-childhood (median age 7.7 years), and adolescence (median age13 years). In this analysis, we will use data from 188 mother-child pairs in Project Viva with available information on prenatal PFAS concentrations, available umbilical cord serum samples at delivery, and outcomes of interest. Please contact MollyAn Killingbeck at mollyan.killingbeck@point32health.org for questions related to the subject characteristics and outcomes. This research was supported by the Environmental influences on Child Health Outcomes (ECHO) program, Office of The Director, National Institutes of Health. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Project Viva is an ECHO cohort which is supported by the following ECHO Program Collaborators: ECHO Coordinating Center: Duke Clinical Research Institute, Durham, North Carolina: Smith PB, Newby KL, Benjamin DK; U2C OD023375 ECHO Data Analysis Center: Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland: Jacobson LP; Research Triangle Institute, Durham, North Carolina: Catellier D; U24 OD023382 North Carolina Human Health Exposure Analysis Resource Hub: Research Triangle Institute: Fennell T, University of North Carolina at Chapel Hill: Sumner S, University of North Carolina at Charlotte: Du X; U2C ES030857 Human Health Exposure Analysis Resource Coordinating Center: Westat, Inc., Rockville, Maryland: O’Brien B; U24 ES026539

ORGANISM(S): Human Homo Sapiens

TISSUE(S): Blood

SUBMITTER: Emily Oken

PROVIDER: ST002336 | MetabolomicsWorkbench | Fri Oct 21 00:00:00 BST 2022

REPOSITORIES: MetabolomicsWorkbench

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Project description:Project Viva: Pregnant women were enrolled in Project Viva between 1999 and 2002 at their first prenatal visit at one of 8 obstetric clinics of Atrius Harvard Vanguard Medical Associates, a multispecialty group practice in eastern Massachusetts. Eligible mothers were fluent in English, had singleton gestations, were <22 weeks gestation, and had no plans to move away from the study area. Research staff performed in-person study visits with participating mothers in the first (median gestational age 9.9 weeks) and second (median gestational age 28.1 weeks) trimesters of pregnancy, and with mothers and children during the first few days after delivery, during infancy (median age 6.3 months), in early childhood (median age 3.3 years), mid-childhood (median age 7.7 years), and adolescence (median age13 years). In this analysis, we will use data from 188 mother-child pairs in Project Viva with available information on prenatal PFAS concentrations, available umbilical cord serum samples at delivery, and outcomes of interest. Please contact Nicole Bornkamp at Nicole_Bornkamp@harvardpilgrim.org for questions related to the subject characteristics and outcomes. This research was supported by the Environmental influences on Child Health Outcomes (ECHO) program, Office of The Director, National Institutes of Health. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Project Viva is an ECHO cohort which is supported by the following ECHO Program Collaborators: ECHO Coordinating Center: Duke Clinical Research Institute, Durham, North Carolina: Smith PB, Newby KL, Benjamin DK; U2C OD023375 ECHO Data Analysis Center: Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland: Jacobson LP; Research Triangle Institute, Durham, North Carolina: Parker CB; U24 OD023382 North Carolina Human Health Exposure Analysis Resource Hub: Research Triangle Institute: Fennell T, University of North Carolina at Chapel Hill: Sumner S, University of North Carolina at Charlotte: Du X; U2C ES030857 Human Health Exposure Analysis Resource Coordinating Center: Westat, Inc., Rockville, Maryland: O’Brien B; U24 ES026539

Project description:Healthy Start is a prospective, pre-birth cohort study that recruited pregnant participants from outpatient prenatal clinics at the University of Colorado Hospital between 2009 and 2014. Eligible participants were 16 years or older with singleton pregnancies, no history of stillbirth or extremely preterm birth (<25 weeks of gestation) and no serious medical conditions, and had not yet completed 24 weeks of gestation at the time of enrollment. Mothers completed two study visits during pregnancy (median gestational ages 17 and 27 weeks). Mother-child pairs were thereafter assessed at birth, and for the child’s follow up, in mid-childhood (median age 4.8 years). For the present project, we will use data from 523 mother-child pairs of the Healthy Start cohort with available information on prenatal PFAS concentrations, available cord plasma samples at delivery, and outcomes of interest. Please contact Wei Perng at wei.perng@cuanschutz.edu for questions related to the subject characteristics and outcomes. This research was supported by the Environmental influences on Child Health Outcomes (ECHO) program, Office of The Director, National Institutes of Health. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Healthy Start is an ECHO cohort which is supported by the following ECHO Program Collaborators: ECHO Coordinating Center: Duke Clinical Research Institute, Durham, North Carolina: Smith PB, Newby KL, Benjamin DK; U2C OD023375 ECHO Data Analysis Center: Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland: Jacobson LP; Research Triangle Institute, Durham, North Carolina: Parker CB; U24 OD023382 North Carolina Human Health Exposure Analysis Resource Hub: Research Triangle Institute: Fennell T, University of North Carolina at Chapel Hill: Sumner S, University of North Carolina at Charlotte: Du X; U2C ES030857 Human Health Exposure Analysis Resource Coordinating Center: Westat, Inc., Rockville, Maryland: O’Brien B; U24 ES026539

Project description:Healthy Start is a prospective, pre-birth cohort study that recruited pregnant participants from outpatient prenatal clinics at the University of Colorado Hospital between 2009 and 2014. Eligible participants were 16 years or older with singleton pregnancies, no history of stillbirth or extremely preterm birth (<25 weeks of gestation) and no serious medical conditions, and had not yet completed 24 weeks of gestation at the time of enrollment. Mothers completed two study visits during pregnancy (median gestational ages 17 and 27 weeks). Mother-child pairs were assessed at birth for neonatal outcomes, and are currently still being followed through 8-10 years postpartum (NB: outcomes for this proposal are at birth). For the present project, we will use data from 1,297 mother-child pairs with adequate maternal plasma at 17 and 27 gestational weeks for untargeted metabolomics profiling. Please contact Wei Perng at wei.perng@cuanschutz.edu for questions related to the subject characteristics and outcomes. This research was supported by the Environmental influences on Child Health Outcomes (ECHO) program, Office of The Director, National Institutes of Health. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Healthy Start is an ECHO cohort which is supported by the following ECHO Program Collaborators: ECHO Coordinating Center: Duke Clinical Research Institute, Durham, North Carolina: Smith PB, Newby KL, Benjamin DK; U2C OD023375 ECHO Data Analysis Center: Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland: Jacobson LP; Research Triangle Institute, Durham, North Carolina: Catellier D; U24 OD023382 North Carolina Human Health Exposure Analysis Resource Hub: Research Triangle Institute: Fennell T, University of North Carolina at Chapel Hill: Sumner S, University of North Carolina at Charlotte: Du X; U2C ES030857 Human Health Exposure Analysis Resource Coordinating Center: Westat, Inc., Rockville, Maryland: O’Brien B; U24 ES026539

Project description:In 2014, the Microbes, Allergy, Asthma and Pets (MAAP) study (P01 AI089473) was launched. All women ages 18-49 years scheduled for prenatal visits at Henry Ford Health, expected to deliver during the recruitment period at a Henry Ford Health hospital, and whose residence was in a predefined area of Detroit and metropolitan Detroit suburbs were potentially eligible. There were no medical insurance requirements. Between 2014 and 2016, 141 women were enrolled; their infant was followed through age 18 months (with continuing follow-up through early/mid childhood underway through the NIH ECHO program under the CREW birth cohort consortium (5UG3OD023282, Gern PI). Blood and stool samples were obtained from the mother prenatally and stool specimens were obtained from the infant at 5 time points (1-week, 1-, 3-, 6- and 18-months) with 16S sequencing already completed. Blood was also obtained from the infant at pre-defined intervals. Please contact Andrea Cassidy-Bushrow at acassid1@hfhs.org for questions related to the subject characteristics and outcomes. This research was supported by the Environmental influences on Child Health Outcomes (ECHO) OIF program, Office of The Director, National Institutes of Health. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. MAAP is an ECHO cohort which is supported by the following ECHO Program Collaborators: ECHO Coordinating Center: Duke Clinical Research Institute, Durham, North Carolina: Smith PB, Newby KL, Benjamin DK; U2C OD023375 ECHO Data Analysis Center: Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland: Jacobson LP; Research Triangle Institute, Durham, North Carolina: Catellier D; U24 OD023382 North Carolina Human Health Exposure Analysis Resource Hub: Research Triangle Institute: Fennell T, University of North Carolina at Chapel Hill: Sumner S, University of North Carolina at Charlotte: Du X; U2C ES030857 Human Health Exposure Analysis Resource Coordinating Center: Westat, Inc., Rockville, Maryland: O’Brien B; U24 ES026539

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Characterizing the intrauterine environment via untargeted metabolomics profiling of maternal blood collected during pregnancy (Project Viva)

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