Discovery of phytochelatins in human urine: Evidence for function in selenium disposition and protection against cadmium
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ABSTRACT: The goal of this project was to detect phytochelatins, plant-derived peptides which function as metal chelators, in human urine. Untargeted metabolomics of 143 urine samples from healthy adults was performed. Phytochelatin 2, γE-C-γE-C-G, was detected, and the rest of the urine metabolome was searched for phytochelatins and predicted phytochelatin metabolites which correlated with phytochelatin 2 concentrations. Phytochelatin 2 and associated metabolites were found to correlate with urinary metals, and further experiments were performed provide insight into function of dietary phytochelatins.
ORGANISM(S): Human Homo Sapiens
TISSUE(S): Urine
SUBMITTER: Zachery Jarrell
PROVIDER: ST002436 | MetabolomicsWorkbench | Tue Jan 10 00:00:00 GMT 2023
REPOSITORIES: MetabolomicsWorkbench
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