Simultaneous targeting of PD-1 and IL2Rβγ with radiation therapy to inhibit pancreatic cancer growth and metastasis
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ABSTRACT: Mice were orthotopically implanted with PK5L1940 cells then radiation therapy (8 Gy) administered 7 days post-implantation. PD1-IL2v and aCD25 dosed once per week beginning day 7 post-implantation. T-cells from spleen were obtained through sorting, cultured in the presence of 13C6 glucose for 6h, and glucose fluxes profiled via mass spectrometry-based metabolomics.
ORGANISM(S): Mouse Mus Musculus
TISSUE(S): T-cells
DISEASE(S): Cancer
SUBMITTER: Julie Haines
PROVIDER: ST002489 | MetabolomicsWorkbench | Tue Feb 21 00:00:00 GMT 2023
REPOSITORIES: MetabolomicsWorkbench
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