Project description:Primary outcome(s): The association of intestinal microbiota with gene mutations and gene expressions and clinicopathological factors in colorectal cancer and inflammatory bowel disease.
Project description:RATIONALE: Inserting a gene that has been created in the laboratory into a person’s white blood cells may make the body build an immune response to kill cancer cells.
PURPOSE: Phase I trial to study the effectiveness of gene therapy in treating patients who have cancer that has not responded to previous therapy.
Project description:This is a Phase I safety study of a gene transfer drug for colorectal cancer that has spread to the liver. The main purpose of this study is to determine if it is safe to give this new intervention to persons with cancer, but we will also look for indications that the drug is effective. Although the findings in animals that have cancer are encouraging, this is the first time humans will receive this experimental gene transfer drug. A gene called cyclin G1 has been shown to play a very important part in cancer growth. In animal experiments, a genetically modified virus (or vector)carrying a modified cyclin G1 gene caused the cancerous tumors to grow much slower or even die. In this safety study, the drug will be injected through the liver artery to get it near the cancer that has spread to the liver. The way the gene gets into the cancer cells is by using a targeted vector that concentrates in the area of the cancer to improve the delivery of the killing gene into cancer cells. The vector we are using is a virus that has been changed so that the infectious genes have been removed and instead carries the modified cyclin G1 gene.
Project description:Analysis of culture extracts from S. coelicolor M1154 with and without the matlystatin gene cluster. Gene cluster with various knock-out mutations.
Project description:RATIONALE: Inserting the interleukin-12 gene into a person’s cancer cells may make the body build an immune response to kill tumor cells.
PURPOSE: This phase I trial is studying the side effects and best dose of interleukin-12 gene when injected into the tumors of patients with liver metastases secondary to colorectal cancer.
Project description:Primary outcome(s): Development of Gene - Environmental interaction risk score methodology and Gene - Environmental Risk Score (GERS) of colorectal cancer;Development of high risk criteria that could be applied final GERS prediction model
Study Design: Observational Study Model : Cohort, Time Perspective : Other(Prospective+Retrospective), Enrollment : 270000, Biospecimen Retention : Collect & Archive- Sample with DNA, Biospecimen Description : whole blood, serum, urine