Ontology highlight
ABSTRACT:
TISSUE(S): B Cell, T Cell
SUBMITTER: Li,Yang
REPOSITORIES: NODE
Liu Chu-Xiao CX Li Xiang X Nan Fang F Jiang Shan S Gao Xiang X Guo Si-Kun SK Xue Wei W Cui Yange Y Dong Kaige K Ding Huihua H Qu Bo B Zhou Zhaocai Z Shen Nan N Yang Li L Chen Ling-Ling LL
Cell 20190425 4
Circular RNAs (circRNAs) produced from back-splicing of exons of pre-mRNAs are widely expressed, but current understanding of their functions is limited. These RNAs are stable in general and are thought to have unique structural conformations distinct from their linear RNA cognates. Here, we show that endogenous circRNAs tend to form 16-26 bp imperfect RNA duplexes and act as inhibitors of double-stranded RNA (dsRNA)-activated protein kinase (PKR) related to innate immunity. Upon poly(I:C) stimu ...[more]