Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Carboxydocella thermautotrophica strain 019

ABSTRACT: Genome sequencing of a C. thermautotrophica strain 019, coupling carbon monoxide oxidation and Fe(III) minerals transformation, isolated from a core sample taken at a thermal field at Uzon caldera, Kamchatka Peninsula, Russia.

PROVIDER: PRJEB11521 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Project description:Uzon Caldera microbial life

| PRJNA623081 | ENA

Project description:Uzon Caldera microbial life

| PRJNA623083 | ENA

hot springs metagenome

Project description:Metagenomic assembled genomes from two thermal pools in the Uzon Caldera, Kamchatka, Russia

| PRJNA419931 | ENA

Corymbia citriodora strain:CV2-019 | cultivar:variegata CV2-019

Project description:Corymbia citriodora strain:CV2-019 | cultivar:variegata CV2-019 Genome sequencing

| PRJNA333374 | ENA

Brucella suis 019

Project description:Brucella suis 019 Genome Sequencing

| PRJNA157955 | ENA

A Pilot Study for Protective Roles of tRNA-Derived Small RNA tRF-Ile-AAT-019 in Pathological Progression of Psoriasis

Project description:Psoriasis is a chronic recurrent inflammatory skin disease that is characterized by abnormal proliferation and differentiation of keratinocytes (KCs), angiogenesis and skin inflammation. tRNA-derived small RNA (tsRNA), including tRNA halves and tRNA fragments (tRFs), is a novel class of short non-coding RNA, possessing regulatory functions in many diseases. However, its role in the pathological development of psoriasis has been unknown. In this pilot study, we conducted small RNA sequencing to screen differentially expressed tRFs in psoriatic skin lesions as compared with normal controls. We found 130 upregulated and 104 downregulated tRFs, among which downregulation of tRF-Ile-AAT-019 in psoriatic skin lesions was further confirmed. Bioinformatics analysis by TargetScan and Miranda algorithms revealed that tRF-Ile-AAT-019 might target SERPINE1, thus regulating HIF-1α signaling pathway. We next showed that increased tRF-Ile-AAT-019 could downregulate expressions of SERPINE1, HIF-1α and vascular proliferative markers such as CD34, CD31, Factor VIII, and VEGF, but upregulate expressions of KCs differentiation markers including Keratin1 and Involucrin. Our data suggest that tRF-Ile-AAT-019 plays a protective role in the pathological progression of psoriasis via targeting SERPINE1 and blocking HIF-1α signaling pathway, leading to control KCs differentiation and vascular proliferation. This data provides a potential novel targeting pathway for the disease treatment.

2021-02-19 | GSE167057 | GEO

RNA-Seq analysis of the TB-019 GSK M72/AS01E trial

Project description:This project involves RNA-Seq analysis of samples obtained from the Phase IIA clinical trial TB-019 (NCT01669096) which evaluated kinetics of response, safety, and immunogenicity of the GSK Mycobacterium tuberculosis (MTB) vaccine M72/AS01E (“GSK M72”). GSK M72 consists of the M72 recombinant fusion of Mycobacterium tuberculosis (MTB) proteins Rv0125 and Rv1196 in combination with the liposome, TLR4 ligand (MPL), and QS21 saponin adjuvant AS01E (Leroux-Roels et al., 2013).

2023-12-30 | GSE102574 | GEO

Brucella suis 019

Project description:Brucella suis 019 Genome sequencing and assembly

| PRJNA308608 | ENA

Panicum virgatum cultivar:SWAG5-019

Project description:Panicum virgatum SWAG5-019 Exome Capture exome

| PRJNA409034 | ENA

Panicum virgatum cultivar:SWAG6-019

Project description:Panicum virgatum SWAG6-019 Exome Capture exome

| PRJNA408979 | ENA