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Energy metabolism in fission yeast

ABSTRACT: Functional and regulatory profiling of energy metabolism in fission yeast

PROVIDER: PRJEB12865 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR1294732.fastq.gz	Fastqsanger.gz
	ERR1294733.fastq.gz	Fastqsanger.gz
	ERR1294734.fastq.gz	Fastqsanger.gz
	ERR1294735.fastq.gz	Fastqsanger.gz

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Functional and Regulatory Profiling of Energy Metabolism in Fission Yeast: dynamic gene regulation during adaptation to respiratory medium.

Project description:Fission yeast in high glucose media preferentially uses fermentation for energy production, even under aerobic conditions, an analogous metabolic programme, aerobic glycolysis, is a hallmark of cancer and enables the proliferation of tumor cells. Fission yeast, unlike budding yeast, requires mitochondrial genomes and oxidative phosphorylation for survival, mitochondrial inheritance, genome organisation and RNA processing are strikingly different between the two yeasts, and S. pombe mitochondria resemble more the human mitochondria. However, mitochondrial biology and respiratory control is poorly understood in fission yeast. In this study, we used microarrays to profile gene expression before and at six time points after the shift from fermentative to respiratory medium. Cells were grown in yeast extract based media with 3% glucose to early exponential phase (time point 0), then the carbon source was changed to 3% glycerol, 0.1% glucose. Transcript levels were monitored by microarrays at several time points after the switch (0.2, 0.5, 1, 2; 04 and 24 hours). Sample from each time point is hybrydized with sample of all pooled time points. Experiment was repeated twice with the dye swap.

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