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Microbial contaminants of jet fuel

ABSTRACT: Microbial contaminants of civil aviation jet fuel supply chains.

PROVIDER: PRJEB20724 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR1957100_1.fastq.gz	Fastqsanger.gz
	ERR1957100_2.fastq.gz	Fastqsanger.gz
	ERR1957110_1.fastq.gz	Fastqsanger.gz
	ERR1957110_2.fastq.gz	Fastqsanger.gz
	ERR1957120_1.fastq.gz	Fastqsanger.gz

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Microbial contaminants of jet fuel

Project description:Microbial contaminants of civil aviation jet fuel supply chains.

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Epigenome-Wide Association Study for Transgenerational Disease Epimutation Sperm Biomarkers following Ancestral Exposure to Jet Fuel Hydrocarbons

Project description:Jet fuel hydrocarbons is the generic name for aviation fuels used in gas-turbine engine powered aircrafts. Due to the widespread use of jet fuel hydrocarbons, this compound has been recognized as the single largest chemical exposure for military personnel. Previous animal studies have demonstrated the ability of jet fuel (JP-8) exposure to promote the epigenetic transgenerational inheritance of disease susceptibility in subsequent generations. The diseases observed include late puberty, kidney, obesity and multiple disease pathologies. The current study was designed to identify potential sperm DNA methylation biomarkers for specific transgenerational diseases. Observations identify few disease specific differential DNA methylation regions (DMRs) called epimutations in the transgenerational F3 generation great-grand-offspring rats ancestrally exposed to jet fuel. The potential epigenetic DMRs were identified for late puberty, kidney, obesity, and multiple diseases, and found to be predominantly disease specific. These disease specific DMRs have associated genes previously shown to be linked with each of these specific diseases. Therefore, the germline (i.e. sperm) has environmentally induced ancestrally derived epimutations that have the potential to transgenerationally transmit disease susceptibilities to subsequent generations. Epigenetic biomarkers for specific diseases could be developed as medical diagnostics to facilitate clinical management of disease and allow preventative medicine therapeutics.

2020-10-01 | GSE155922 | GEO

Expression data for P. aeruginosa ATCC 33988 and P. aeruginosa PAO1 in Jet-A fuel

Project description:We investigated fuel specific transcriptomic differences between these strains in order to ascertain the underlying mechanisms utilized by the adapted strain P. aeruginosa ATCC 33988 to jet fuel to Jet-fuel During growth in fuel, the genes related to alkane degradation, heat-shock response, membrane proteins, efflux pumps and several novel genes were upregulated in ATCC 33988

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Hydrocarbons (Jet Fuel JP-8) Induce Epigenetic Transgenerational Inheritance of Obesity, Reproductive Disease and Sperm Epimutations

Project description:Environmental compounds have been shown to promote epigenetic transgenerational inheritance of disease. The current study was designed to determine if a hydrocarbon mixture involving jet fuel (JP-8) promotes epigenetic transgenerational inheritance of disease. Gestating F0 generation female rats were transiently exposed during the fetal gonadal development period. The direct exposure F1 generation had an increased incidence of kidney abnormalities in both females and males, prostate and pubertal abnormalities in males, and primordial follicle loss and polycystic ovarian disease in females. The first transgenerational generation is the F3 generation, and the jet fuel lineage had an increased incidence of primordial follicle loss and polycystic ovarian disease in females, and obesity in both females and males. Analysis of the jet fuel lineage F3 generation sperm epigenome identified 33 differential DNA methylation regions, termed epimutations. Observations demonstrate hydrocarbons can promote epigenetic transgenerational inheritance of disease and sperm epimutations, potential biomarkers for ancestral exposures. Methylated sperm DNA was isolated from rats ancestrally exposed to jet fuel (Jip). Three independent samples from the treatment group were obtained. Differential DNA methylation between treatment groups was determined using Nimblegen microarrays. Treated samples were paired with control samples and hybridized together on arrays (Jip1/Cip1, Jip2/Cip2, and Jip3/Cip3), resulting in three arrays for the treatment.

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Hydrocarbons (Jet Fuel JP-8) Induce Epigenetic Transgenerational Inheritance of Obesity, Reproductive Disease and Sperm Epimutations

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