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Transcriptional profiling of articular cartilage in a porcine model of early post-traumatic osteoarthritis

ABSTRACT: Transcriptional profiling of articular cartilage in a porcine model of early post-traumatic osteoarthritis

PROVIDER: PRJEB22000 | ENA |

REPOSITORIES: ENA

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Transcriptional profiling of articular cartilage in a porcine model of early post-traumatic osteoarthritis

Project description:36 Yucatan minipigs underwent anterior cruciate ligament (ACL) transection and were randomly assigned in equal numbers to no further treatment, reconstruction or ligament repair. Cartilage was harvested at 1 and 4 weeks post-operatively and histology and RNA-sequencing performed. The generated data served to identify the molecular pathophysiology present in early post-traumatic osteoarthritis (PTOA), as well as differences between surgical treatments.

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Project description:Lef1 Ablation Alleviates Cartilage Mineralization during Post-traumatic Osteoarthritis

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