Project description:We investigated the role of PME-1 (protein phosphatase methylesterase-1) as a specific methylesterase for the critical cancer suppressor, protein phosphatase 2A (PP2A), and its potential contributions to the development and malignancy of various cancers. Notably, no gene expression database related to PME-1 deficiency had been previously reported. To address this knowledge gap, we conducted an analysis of the impact of PME-1 on gene expression using mouse embryonic fibroblasts (MEFs) isolated from both PME-1 wild-type (WT) and knockout (KO) mice.
Project description:We wanted to explore the relative contributions of DNA binding and tethering regulation modes by the estrogen receptor in human breast cancer cells We defined the genome-wide localization of WT and DBDmut estrogen receptors in human breast cancer cells
