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The polycyclic polyprenylated acylphloroglucinol antibiotic PPAP 23 targets iron metabolism

ABSTRACT: Staphylococcus aureus was exposed to polycyclic polyprenylated acylphloroglucinols (PPAP) derivatives at different times of growth. The antimicrobial mechanism of PPAP 23 was investigated by RNA-seq combined with various biochemical approaches. Our results suggest that PPAP 23 interact with the cytoplasmic membrane of Gram-positive bacteria yielding to bacterial cell death.

PROVIDER: PRJEB28806 | ENA |

REPOSITORIES: ENA

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