Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Zika virus genome sequencing field mosquitoes

ABSTRACT: Zika virus genome sequencing directly from field collected mosquitoes

PROVIDER: PRJEB29404 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

RNA sequencing of Aedes mosquitoes infected with Zika virus (ZIKV) or Dengue virus (DENV)

Project description:Zika virus (ZIKV), a pathogen of global health concern, is transmitted to humans by Aedes mosquitoes. However, the molecular interactions between the vector and the virus remain largely unexplored. We demonstrated that ZIKV and dengue virus (DENV) have similar tropism and infection kinetics in two mosquito strains with different degrees of susceptibility to infection. Comparison of Aedes aegypti’s molecular responses to ZIKV and DENV infection indicated that around 40% of the mosquito’s infection-responsive transcriptome is virus-specific. Regulated genes also included key factors of the mosquito’s anti-viral immunity, pointing to the possible involvement of the Toll innate immune pathway. Comparison of ZIKV and DENV infection-responsive transcriptome data to those for yellow fever virus and West Nile virus identified 26 genes likely to play key roles in virus infection of Aedes mosquitoes. Through reverse genetic analyses, we showed that the Toll and the Jak/Stat innate immune pathways mediate increased resistance to ZIKV infection, and the virus use vATPase and inosine-5’-monophosphate dehydrogenase as mosquito’s host factors.

2017-11-07 | GSE96605 | GEO

Mouse skin samples after Zika virus-infected mosquito bites

Project description:Mouse skin bitten by Zika virus-infected mosquitoes were isolated and performed RNA-seq

2019-03-10 | GSE125194 | GEO

Zika virus

Project description:Zika virus genomes directly sequenced from clinical samples collected from Colombia, January, 2016

| PRJNA358078 | ENA

Global transcriptome analysis of Aedes aegypti mosquitoes in response to Zika virus infection

Project description:Zika virus (ZIKV) of the Flaviviridae family is a recently emerged mosquito-borne virus that has been implicated in the surge of the number of microcephaly instances in south America. The virus is transmitted mainly by the mosquito Aedes aegypti that also vectors dengue virus. Considering rather recent rapid spread of the virus and its declaration as a global health emergency by the World Health Organization, little is known about the interactions of the virus with the mosquito vector. In this study, we investigated the transcriptome profiles of whole Ae. aegypti mosquitoes in response to ZIKV infection at 2, 7 and 14 days post-infection using deep sequencing. Results showed a large number of transcripts were altered at each time point following infection, but 18 transcripts were commonly changed at the three time points. The outcomes provide a basic understanding of Ae. aegypti responses to ZIKV and help determining host factors involved in replication or anti-viral response against the virus.

2017-10-27 | GSE102939 | GEO

Zika virus

Project description:Zika Virus Virus genome sequencing

| PRJNA336379 | ENA

Zika virus

Project description:Zika virus stock sequences

| PRJNA476611 | ENA

Zika virus

Project description:Zika virus Genome sequencing

| PRJNA315525 | ENA

Zika virus

Project description:Zika virus Genome sequencing

| PRJNA344504 | ENA

Microarray analysis of MRC-5 cells infected with Zika virus strains

Project description:To better understand the critical drivers of Zika virus pathogenicity, we used microarray analysis to evaluate the host responses triggered by Zika virus infection in MRC-5 cells.

2021-03-23 | E-MTAB-10292 | biostudies-arrayexpress

Zika virus

Project description:Zika virus Raw sequence reads

| PRJNA498737 | ENA