Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABRES dairy cattle

ABSTRACT: Dynamics of faecal shedding of Extended Spectrum beta-Lactamase or AmpC-producing Escherichia coli on dairy farms

PROVIDER: PRJEB30024 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	ERR2987470_1.fastq.gz	Fastqsanger.gz
	ERR2987470_2.fastq.gz	Fastqsanger.gz
	ERR2987480_1.fastq.gz	Fastqsanger.gz
	ERR2987480_2.fastq.gz	Fastqsanger.gz
	ERR2987490_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 316

Similar Datasets

Project description:Extended spectrum cephalosporin-resistant Escherichia coli on dairy farms

| PRJNA491471 | ENA

Project description:Extended Spectrum beta-Lactamase-producing Enterobacteriaceae shedding by race horses in Ontario, Canada

| PRJNA612199 | ENA

ESBL producing E. coli from horses

Project description:Fecal carriage of Extended Spectrum beta-Lactamase (ESBL)/ AmpC-producing Escherichia coli in horses

| PRJEB34847 | ENA

Project description:Extended-Spectrum Beta-Lactamase gene sequencing

| PRJNA825737 | ENA

Microbiome and Salmonella in periparturient dairy cattle

Project description:Fecal microbiome of periparturient dairy cattle and associations with the onset of Salmonella shedding

| PRJEB25138 | ENA

Dairy Cattle Manure

Project description:Dairy Cattle Manure Raw sequence reads

| PRJNA701469 | ENA

Dairy cattle rumen microbiome

Project description:Whole genome shotgun data from dairy catttle

| PRJEB33080 | ENA

Cefazolin and Imipenem Enhance AmpC Expression and Resistance in NagZ-dependent manner in Enterobacter cloacae complex

Project description:Background: Enterobacter cloacae complex (ECC) is a common opportunistic pathogen and is responsible for causing various infections in humans. Owing to its inducible chromosomal AmpC β-lactamase (AmpC), ECC is inherently resistant to the 1st- and 2nd- generation cephalosporins. However, whether β-lactams antibiotics enhance ECC resistance remains unclear. Results: In this study, we found that subinhibitory concentrations (SICs) of cefazolin (CFZ) and imipenem (IMP) can advance the expression of AmpC and enhance its resistance towards β-lactams through NagZ in Enterobacter cloacae (EC). Further, AmpC manifested a substantial upregulation in EC in response to SICs of CFZ and IMP. In nagZ knockout EC (ΔnagZ), the resistance to β-lactam antibiotics was rather weakened and the effect of CFZ and IMP on AmpC induction was completely abrogated. NagZ ectopic expression can rescue the induction effects of CFZ and IMP on AmpC and increase ΔnagZ resistance. More importantly, CFZ and IMP have the potential to induce the expression of AmpR's target genes in a NagZ-dependent manner. Conclusions: Our findings suggest that NagZ is a critical determinant for CFZ and IMP to promote AmpC expression and resistance and that CFZ and IMP should be used with caution since they may aggravate ECC resistance. At the same time, this study further improves our understanding of resistance mechanisms in ECC.

2022-07-01 | GSE207144 | GEO

Extended Spectrum Beta-Lactamase-producing Enterobacteriaceae

Project description:Extended Spectrum Beta-Lactamase-producing Enterobacteriaceae Raw sequence reads

| PRJNA476828 | ENA

Fecal Microbiota Transplantation for Extended-Spectrum Beta Lactamase Carriers.

Project description:Fecal Microbiota Transplantation for Extended-Spectrum Beta Lactamase Carriers.

| PRJEB46779 | ENA