Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Major changes in chromosomal somy, gene expression and gene dosage 2 driven by SbIII in Leishmania braziliensis and Leishmania panamensis

ABSTRACT: Major changes in chromosomal somy, gene expression and gene dosage driven by SbIII in Leishmania braziliensis and Leishmania panamensis

PROVIDER: PRJEB31092 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	ERR3309140_1.fastq.gz	Fastqsanger.gz
	ERR3309140_2.fastq.gz	Fastqsanger.gz
	ERR3309150_1.fastq.gz	Fastqsanger.gz
	ERR3309150_2.fastq.gz	Fastqsanger.gz
	ERR3309141_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 40

Similar Datasets

Major changes in chromosomal somy, gene expression and gene dosage 2 driven by SbIII in Leishmania braziliensis and Leishmania panamensis

Project description:Major changes in chromosomal somy, gene expression and gene dosage driven by SbIII in Leishmania braziliensis and Leishmania panamensis

| PRJEB31092 | ENA

Leishmania braziliensis

Project description:Leishmania braziliensis Genome sequencing

| PRJNA475480 | ENA

Differential gene expression between uninfected and infected U937 derived macrophages with Leishmania braziliensis

Project description:The main objective of this study is to identify the list of genes differentially expressed between infected with Leishmania braziliensis and non-infected macrophage cultures based on gene expression microarray profiling The dataset is comprised by the expression profile of 6 samples from three independent experiments and each experiment had three technical replicates. 3 of the 6 samples were U937 derived macrophages infected by Leishmania braziliensis and the other 3 were U937 derived macrophages without infection with Leishmania braziliensis. A total of 18 microarrays analysis were performed.

2015-06-10 | E-GEOD-61211 | biostudies-arrayexpress

Leishmania braziliensis

Project description:Leishmania braziliensis Genome sequencing and assembly

| PRJNA292004 | ENA

Leishmania panamensis

Project description:Clinical isolates of Leishmania panamensis from Panama

| PRJNA859191 | ENA

Differential gene expression between uninfected and infected U937 derived macrophages with Leishmania braziliensis

2015-06-10 | GSE61211 | GEO

Leishmania braziliensis strain:M2903

Project description:Leishmania braziliensis siRNA sequencing

| PRJNA176736 | ENA

Leishmania panamensis

Project description:Genomic changes associated with environmental conditions in Leishmania panamensis

| PRJNA558039 | ENA

Leishmania braziliensis guyanensis

Project description:Leishmania braziliensis strain 2700 small RNA

| PRJNA335424 | ENA

Major changes in chromosomal somy, gene expression and gene dosage driven by Sb<sup>III</sup> in Leishmania braziliensis and Leishmania panamensis.

Project description:Leishmania braziliensis and Leishmania panamensis are two species clinically and epidemiologically important, among others because of their relative resistance to first-line drugs (antimonials). The precise mechanism underlying the ability of these species to survive antimony treatment remains unknown. Therefore, elucidating the pathways mediating drug resistance is essential. We herein experimentally selected resistance to trivalent antimony (SbIII) in the reference strains of L. braziliensis (MHOM/BR75/M2904) and L. panamensis (MHOM/COL/81L13) and compared whole genome and transcriptome alterations in the culture promastigote stage. The results allowed us to identify differences in somy, copy number variations in some genes related to antimony resistance and large-scale copy number variations (deletions and duplications) in chromosomes with no somy changes. We found mainly in L. braziliensis, a direct relation between the chromosomal/local copy number variation and the gene expression. We identified differentially expressed genes in the resistant lines that are involved in antimony resistance, virulence, and vital biological processes in parasites. The results of this study may be useful for characterizing the genetic mechanisms of these Leishmania species under antimonial pressure, and for clarifying why the parasites are resistant to first-line drug treatments.

| S-EPMC6603004 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data