Project description:Longitudinal sampling of Listeria monocytogenes from food processing plants reveals genomic diversity and dates the emergence of persisting sequence types of this food-borne pathogen

| PRJEB14063 | ENA

Bioremediation of a common product of food processing by a human gut bacterium

Project description:Bioremediation of a common product of food processing by a human gut bacterium

2019-08-27 | MSV000084239 | MassIVE

PRC2 Heterogeneity Drives Tumor Growth in Medulloblastoma [mouse]

Project description:PRC2 Heterogeneity Drives Tumor Growth in Medulloblastoma [mouse]

| PRJNA848790 | ENA

PRC2 Heterogeneity Drives Tumor Growth in Medulloblastoma [Human]

Project description:PRC2 Heterogeneity Drives Tumor Growth in Medulloblastoma [Human]

| PRJNA848779 | ENA

Widespread consumption of the common food additive xanthan gum by the human gut microbiota

Project description:The diets of industrialized countries reflect the increasing use of processed foods, often with the inclusion of novel food additives. Xanthan gum is a complex polysaccharide with unique rheological properties that have established its use as a widespread stabilizer and thickening agent. Xanthan gum’s chemical structure is distinct from the host and dietary polysaccharides that are more commonly expected to transit the gastrointestinal tract, and little is known about its direct interaction with the gut microbiota, which plays a central role in digestion of other dietary fiber polysaccharides. Here, we show that the ability to digest xanthan gum is surprisingly common in industrialized human gut microbiomes and appears contingent on a single uncultured bacterium in the family Ruminococcaceae. Our data reveal that this primary degrader cleaves the xanthan gum backbone before processing the released oligosaccharides using additional enzymes. Surprisingly, some individuals harbor a Bacteroides intestinalis that is incapable of consuming polymeric xanthan gum but grows on oligosaccharide products generated by the Ruminococcaceae. Feeding xanthan gum to germfree mice colonized with a human microbiota containing the uncultured Ruminococcaceae supports the idea that this additive can drive expansion of this primary degrader along with exogenously introduced Bacteroides intestinalis. Our work demonstrates the existence of a potential xanthan gum food chain involving at least two members of different phyla of gut bacteria and provides an initial framework to understand how widespread consumption of a recently introduced food additive influences human microbiomes.

2022-02-28 | PXD031522 | Pride

Prediction of clinical reactivity in food sensitized individuals from blood DNA methylation profiles

Project description:Genome wide DNA methylation profiling study of PBMC from 71 unique primary patient blood samples. The Illumina Human Methylation 450k array was used. 29 challenge proven food allergy, 29 sensitized but oral tolerant, 13 non food allergics Mixture of food allergy phenotypes (egg allergic (15), peanut allergic (14)), food sensitization phenotypes (egg sensitized (14), peanut sensitized (15)). 4 samples had technical replicate hybridzations. Bisulphite converted DNA from the 75 samples were hybridised to the Illumina Infinium 450k Human Methylation Beadchip v1.2. Technical replicates were combined during processing, resulting in normalized Beta values for 71 unique primary patient blood samples.

2015-01-01 | E-GEOD-59999 | biostudies-arrayexpress

food production metagenome

Project description:Evaluation of the effects of enzymatic cleaning on food processing installation and food product bacterial microflora

| PRJNA615390 | ENA