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Genomic epidemiology on S. Infantis in Ecuador

ABSTRACT: Genomic Epidemiology of Salmonella Infantis in Ecuador: From Poultry Farms to Human Infections

PROVIDER: PRJEB37560 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	ERR4844970_1.fastq.gz	Fastqsanger.gz
	ERR4844970_2.fastq.gz	Fastqsanger.gz
	ERR4844990_1.fastq.gz	Fastqsanger.gz
	ERR4844990_2.fastq.gz	Fastqsanger.gz

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Genomic Epidemiology of <i>Salmonella</i> Infantis in Ecuador: From Poultry Farms to Human Infections.

Project description:Salmonella enterica is one of the most important foodborne pathogens around the world. In the last years, S. enterica serovar Infantis has become an important emerging pathogen in many countries, often as multidrug resistant clones. To understand the importance of S. enterica in the broiler industry in Ecuador, we performed a study based on phenotypic and WGS data of isolates from poultry farms, chicken carcasses and humans. We showed a high prevalence of S. enterica in poultry farms (41.4%) and chicken carcasses (55.5%), but a low prevalence (1.98%) in human samples. S. Infantis was shown to be the most prevalent serovar with a 98.2, 97.8, and 50% in farms, foods, and humans, respectively, presenting multidrug resistant patterns. All sequenced S. Infantis isolates belonged to ST32. For the first time, a pESI-related megaplasmid was identified in Ecuadorian samples. This plasmid contains genes of antimicrobial resistance, virulence factors, and environmental stress tolerance. Genomic analysis showed a low divergence of S. Infantis strains in the three analyzed components. The results from this study provide important information about genetic elements that may help understand the molecular epidemiology of S. Infantis in Ecuador.

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